Invitrogen

alpha Catenin Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

View all (11) alpha Catenin antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-120932

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunoprecipitation (IP)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human alpha-Catenin (NP_0018942)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914504

Product Specific Information

Positive test controls include: BT-474, OVCAR3, 293T, MCF7, Mouse lung, Mouse heart, Mouse brain. The target is usually found in the following locations: Cell junction, Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, adherens junction, cytoskeleton.

Immunogen sequence: ELDDSDFETE DFDVRSRTSV QTEDDQLIAG QSARAIMAQL PQEQKAKIAE QVASFQEEKS KLDAEVSKWD DSGNDIIVLA KQMCMIMMEM TDFTRGKGPL KNTSDVISAA KKIAEAGSRM DKLGRTIADH CPDSACKQDL LAYLQRIALY CHQLNICSKV KAEVQNLGGE LVVSGVDSAM SLIQAAKNLM NAVVQTVKAS YVASTKYQKS QGMASLNLPA VSWKMKAPEK KPLVKREKQD ETQTKIKRAS QKKHVNPVQA LSEFKAMDSI

Target Information

Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 102 kDa cadherin-associated protein; alpha E catenin; Alpha E-catenin; Alpha N-catenin; alpha(E)-catenin; alpha(N)-catenin; alpha-catenin; Alpha-catenin-related protein; alpha-E-catenin; alpha-N-catenin; alphaE-catenin; alphaN-catenin; cadherin associated protein; Cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; CAP102; catenin; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; catenin alpha 1; catenin alpha 2; Catenin alpha-1; Catenin alpha-2; Catenin alpha1; Catenin alpha2; catenin, alpha 1; Catenin-alpha1; Catenin-alpha2; cerebellar deficient folia; FLJ36832; FLJ52416; HGNC:2509; NY-REN-13 antigen; Renal carcinoma antigen NY-REN-13

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Gene Aliases: 2010010M04Rik; AA517462; AI481747; AI988031; CAP-R; CAP102; CAPR; Catna; Catna1; Catna2; cdf; chp; CT114; CTNNA1; CTNNA2; CTNR; MDPT2

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UniProt ID: (Human) P35221, (Human) P26232, (Mouse) P26231, (Mouse) Q61301

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Entrez Gene ID: (Human) 1495, (Human) 1496, (Rat) 307505, (Mouse) 12385, (Mouse) 12386, (Rat) 297357

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Function(s)
structural molecule activity protein binding beta-catenin binding vinculin binding poly(A) RNA binding gamma-catenin binding cadherin binding actin filament binding cadherin binding involved in cell-cell adhesion structural constituent of cytoskeleton non-motor actin binding protein
Process(es)
ovarian follicle development actin filament organization cell adhesion establishment or maintenance of cell polarity negative regulation of neuroblast proliferation aging male gonad development gap junction assembly axon regeneration adherens junction organization cellular protein localization odontogenesis of dentin-containing tooth apical junction assembly response to estrogen positive regulation of smoothened signaling pathway positive regulation of muscle cell differentiation protein heterooligomerization cellular response to indole-3-methanol epithelial cell-cell adhesion negative regulation of cell motility negative regulation of integrin-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of extrinsic apoptotic signaling pathway in absence of ligand cytoskeleton organization axonogenesis single organismal cell-cell adhesion radial glia guided migration of Purkinje cell dendrite morphogenesis brain morphogenesis regulation of synapse structural plasticity prepulse inhibition response to organic cyclic compound regulation of cell proliferation negative regulation of apoptotic process multicellular organism development cell differentiation
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