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alpha Synuclein Antibody (MA5-47396) in IHC (PFA)
Immunohistochemistry analysis of alpha Synuclein in rat cerebellum section. Samples were stained with alpha Synuclein monoclonal antibody (Product # MA5-47396) using a dilution of 1:1,000 (red). Costained with rabbitpAb to GFAPdilution 1:5,000 in green. The blue is Hoechst staining of nuclear DNA. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 ... View More
Product Details
MA5-47396
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A7
Immunogen
Full length human recombinant protein expressed in and purified from E. coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2942378
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha synuclein; Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: alphaSYN; NACP; PARK1; PARK4; PD1; SNCA; Syn
UniProt ID: (Human) P37840, (Bovine) Q3T0G8, (Pig) Q3I5G7, (Rat) P37377, (Mouse) O55042
Entrez Gene ID: (Human) 6622, (Bovine) 282857, (Pig) 641350, (Rat) 29219, (Mouse) 20617
magnesium ion binding
fatty acid binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
ferrous iron binding
zinc ion binding
oxidoreductase activity
kinesin binding
protein domain specific binding
histone binding
identical protein binding
alpha-tubulin binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
phospholipase binding
transcription regulatory region DNA binding
dynein binding
protein N-terminus binding
tau protein binding
beta-tubulin binding
phosphoprotein binding
phospholipase D inhibitor activity
arachidonic acid binding
SNARE binding
actin binding
Hsp70 protein binding
dynein complex binding
cuprous ion binding
enzyme binding
metal ion binding
membrane trafficking regulatory protein
negative regulation of transcription from RNA polymerase II promoter
microglial cell activation
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial membrane organization
aging
adult locomotory behavior
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
cellular response to oxidative stress
negative regulation of histone acetylation
regulation of locomotion
dopamine biosynthetic process
response to drug
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
extracellular fibril organization
negative regulation of neuron apoptotic process
cellular protein metabolic process
cellular response to fibroblast growth factor stimulus
positive regulation of endocytosis
negative regulation of exocytosis
negative regulation of dopamine metabolic process
behavioral response to cocaine
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synapse organization
regulation of acyl-CoA biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
dopamine uptake involved in synaptic transmission
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
calcium ion homeostasis
oxidation-reduction process
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
cellular response to copper ion
cellular response to epinephrine stimulus
positive regulation of protein serine/threonine kinase activity
negative regulation of neuron death
negative regulation of mitochondrial electron transport, NADH to ubiquinone
positive regulation of glutathione peroxidase activity
positive regulation of hydrogen peroxide catabolic process
regulation of synaptic vesicle recycling
regulation of reactive oxygen species biosynthetic process
negative regulation of chaperone-mediated autophagy
synaptic transmission, dopaminergic
SNARE complex assembly
synaptic vesicle transport
protein oligomerization
regulation of reactive oxygen species metabolic process
synaptic vesicle priming
regulation of transmembrane transporter activity
positive regulation of SNARE complex assembly
positive regulation of exocytosis
positive regulation of inflammatory response
protein tetramerization
positive regulation of neuron death
regulation of presynapse assembly
chemical synaptic transmission
response to cocaine
dopamine metabolic process
regulation of neuron apoptotic process
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of synaptic transmission
membrane organization
regulation of neuron death
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