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alpha + beta Synuclein Antibody (BS-0012M) in IHC (P)
Formalin-fixed and paraffin-embedded rat brain labeled with Mouse Anti-Alpha-Synuclein Polyclonal Antibody, Unconjugated(bs-0012M) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.
Product Details
BS-0012M
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Alpha-Synuclein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-synuclein; Beta-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Phosphoneuroprotein 14; PNP 14; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: AI838531; alphaSYN; betaSYN; NACP; PARK1; PARK4; PD1; SNCA; SNCB; Syn
UniProt ID: (Human) P37840, (Human) Q16143, (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754
Entrez Gene ID: (Human) 6622, (Human) 6620, (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893
magnesium ion binding
fatty acid binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
ferrous iron binding
zinc ion binding
oxidoreductase activity
kinesin binding
protein domain specific binding
histone binding
identical protein binding
alpha-tubulin binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
phospholipase binding
transcription regulatory region DNA binding
dynein binding
protein N-terminus binding
tau protein binding
beta-tubulin binding
phosphoprotein binding
phospholipase D inhibitor activity
phospholipase inhibitor activity
enzyme binding
Hsp70 protein binding
arachidonic acid binding
metal ion binding
membrane trafficking regulatory protein
negative regulation of transcription from RNA polymerase II promoter
microglial cell activation
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial membrane organization
aging
adult locomotory behavior
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
cellular response to oxidative stress
negative regulation of histone acetylation
regulation of locomotion
dopamine biosynthetic process
response to drug
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
extracellular fibril organization
negative regulation of neuron apoptotic process
cellular protein metabolic process
cellular response to fibroblast growth factor stimulus
positive regulation of endocytosis
negative regulation of exocytosis
negative regulation of dopamine metabolic process
behavioral response to cocaine
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synapse organization
regulation of acyl-CoA biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
dopamine uptake involved in synaptic transmission
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
calcium ion homeostasis
oxidation-reduction process
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
cellular response to copper ion
cellular response to epinephrine stimulus
positive regulation of protein serine/threonine kinase activity
negative regulation of neuron death
negative regulation of mitochondrial electron transport, NADH to ubiquinone
positive regulation of glutathione peroxidase activity
positive regulation of hydrogen peroxide catabolic process
regulation of synaptic vesicle recycling
regulation of reactive oxygen species biosynthetic process
negative regulation of chaperone-mediated autophagy
chemical synaptic transmission
dopamine metabolic process
negative regulation of catalytic activity
synaptic transmission, dopaminergic
response to cocaine
regulation of neuron apoptotic process
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
synaptic vesicle transport
positive regulation of synaptic transmission
membrane organization
regulation of neuron death
regulation of reactive oxygen species metabolic process
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