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alpha-synuclein Polyclonal Antibody

alpha-synuclein Antibody in Immunocytochemistry (ICC/IF)

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alpha-synuclein Antibody (10842-1-AP) in ICC/IF

Immunofluorescent analysis of SH-SY5Y cells using 10842-1-AP (alpha-synuclein antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

alpha-synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))

alpha-synuclein Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

alpha-synuclein Antibody in Western Blot (WB)

Product Image Gallery

Product Details

10842-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 39 publications 39 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:10-1:100

Immunocytochemistry (ICC/IF)

1:10-1:100

View 10 publications 10 publications

ELISA (ELISA)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Avian, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

alpha-synuclein Fusion Protein Ag1285 (1-140 aa encoded by BC013293)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.51 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize all the isoforms of alpha-syn.

Immunogen sequence: MDVFMKGLS KAKEGVVAAA EKTKQGVAEA AGKTKEGVLY VGSKTKEGVV HGVATVAEKT KEQVTNVGGA VVTGVTAVAQ KTVEGAGSIA AATGFVKKDQ LGKNEEGAPQ EGILEDMPVD PDNEAYEMPS EEGYQDYEPE A (1-140 aa encoded by BC013293)

Target Information

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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