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beta 1-Adrenergic Receptor (extracellular) Polyclonal Antibody, FITC

View all (14) beta-1 Adrenergic Receptor antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AAR-023-F-50UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)RAESDEARR(S)YNDP, corresponding to amino acid residues 200-214 of rat ADRB1, Extracellular, 2nd loop
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Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism. In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system. Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta 1-AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; cardiac beta adrenergic receptor

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Gene Aliases: Adrb-1; ADRB1; ADRB1R; B1AR; beta-AR; BETA1AR; RATB1AR; RHR

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UniProt ID: (Human) P08588, (Mouse) P34971, (Rat) P18090

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Entrez Gene ID: (Human) 153, (Mouse) 11554, (Rat) 24925

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Function(s)
beta-adrenergic receptor activity beta1-adrenergic receptor activity receptor signaling protein activity Ras guanyl-nucleotide exchange factor activity protein binding PDZ domain binding alpha-2A adrenergic receptor binding protein heterodimerization activity epinephrine binding norepinephrine binding signal transducer activity G-protein coupled receptor activity adrenergic receptor activity drug binding dopamine binding G-protein coupled receptor
Process(es)
temperature homeostasis positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure activation of adenylate cyclase activity cell-cell signaling response to cold positive regulation of cAMP biosynthetic process heat generation negative regulation of multicellular organism growth fear response positive regulation of GTPase activity positive regulation of cAMP-mediated signaling brown fat cell differentiation adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of the force of heart contraction by norepinephrine positive regulation of systemic arterial blood pressure glycogen catabolic process apoptotic process signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway Rho protein signal transduction memory positive regulation of heart rate sensory perception of pain protein localization to organelle negative regulation of urine volume wound healing positive regulation of apoptotic process positive regulation of adenylate cyclase activity positive regulation of heart contraction negative regulation of smooth muscle contraction positive regulation of saliva secretion regulation of calcium ion transport lipid homeostasis inhibitory postsynaptic potential positive regulation of cell growth involved in cardiac muscle cell development adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction positive regulation of renin secretion into blood stream positive regulation of long-term synaptic potentiation positive regulation of cation channel activity aging
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