Product References
Multimodal Assessment of Bottlenose Dolphin Auditory Nuclei Using 7-Tesla MRI, Immunohistochemistry and Stereology.
Veterinary sciences
Orekhova K,Selmanovic E,De Gasperi R,Gama Sosa MA,Wicinski B,Maloney B,Seifert A,Alipour A,Balchandani P,Gerussi T,Graïc JM,Centelleghe C,Di Guardo G,Mazzariol S,Hof PR
700254 was used in Immunohistochemistry to assess the connectivity of the inferior colliculi and ventral cochlear nuclei using diffusion tensor imaging (DTI).
Tue Dec 13 00:00:00 EST 2022
Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice.
Molecular neurodegeneration
Cuddy LK,Alia AO,Salvo MA,Chandra S,Grammatopoulos TN,Justman CJ,Lansbury PT,Mazzulli JR,Vassar R
700254 was used in Immunohistochemistry-immunofluorescence to show that the results agree with previous work identifying FTase as a therapeutic target for treating proteinopathies and could have important therapeutic implications in treating AD.
Sat Aug 20 00:00:00 EDT 2022
Amyloid Pathology in the Central Auditory Pathway of 5XFAD Mice Appears First in Auditory Cortex.
Journal of Alzheimer's disease : JAD
Weible AP,Wehr M
700254 was used in Immunohistochemistry to suggest that Aβ42 accumulation, but not plaques, may impair gap detection.
Tue Oct 18 00:00:00 EDT 2022
Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis.
PloS one
Sadleir KR,Popovic J,Khatri A,Vassar R
700254 was used in Dot blot to conclude that nimodipine treatment is not likely to improve amyloid pathology or decrease neuritic dystrophy in AD, it is worth noting that nimodipine did not worsen the phenotype suggesting its use is safe in AD patients.
Fri Feb 25 00:00:00 EST 2022
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta neuropathologica
Roos TT,Garcia MG,Martinsson I,Mabrouk R,Israelsson B,Deierborg T,Kobro-Flatmoen A,Tanila H,Gouras GK
700254 was used in Immunocytochemistry, Immunohistochemistry to indicate an essential role for intracellular prion-like Aβ and its synaptic spread in the pathogenesis of AD.
Fri Oct 01 00:00:00 EDT 2021
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis.
Acta neuropathologica
Roos TT,Garcia MG,Martinsson I,Mabrouk R,Israelsson B,Deierborg T,Kobro-Flatmoen A,Tanila H,Gouras GK
700254 was used in Immunocytochemistry, Immunohistochemistry to indicate an essential role for intracellular prion-like Aβ and its synaptic spread in the pathogenesis of AD.
Fri Oct 01 00:00:00 EDT 2021
Pharmacological intervention in a transgenic mouse model improves Alzheimer's-associated pathological phenotype: Involvement of proteasome activation.
Free radical biology & medicine
Mladenovic Djordjevic AN,Kapetanou M,Loncarevic-Vasiljkovic N,Todorovic S,Athanasopoulou S,Jovic M,Prvulovic M,Taoufik E,Matsas R,Kanazir S,Gonos ES
700254 was used in Immunocytochemistry to test if the activation of proteasome in vivo can alleviate Alzheimer's disease pathology.
Fri Jan 01 00:00:00 EST 2021
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Hinteregger B,Loeffler T,Flunkert S,Neddens J,Bayer TA,Madl T,Hutter-Paier B
700254 was used in Immunohistochemistry to provide a comprehensive characterization of the Tg4-42 mouse model which could lead to a deeper understanding of pathological features of AD.
Tue Sep 14 00:00:00 EDT 2021
Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains.
International journal of molecular sciences
Jankovska N,Olejar T,Matej R
700254 was used in Immunohistochemistry (Paraffin) to show that PrPSc aggregation could dominate during co-aggregation with non-compact Aβ in the periphery of Aβ plaques.
Sat Feb 20 00:00:00 EST 2021
Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer's disease.
Aging
Zhang T,Shen Y,Guo Y,Yao J
700254 was used in Western Blot to identify several key transcriptome biomarkers, which promoted the prediction and diagnosis of AD.
Mon May 24 00:00:00 EDT 2021
Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data.
International journal of molecular sciences
Jankovska N,Matej R,Olejar T
700254 was used in Immunohistochemistry to study GSS plaques' micromorphology and protein composition. Found small, condensed plaques dominate; dystrophic neuritic changes with tau or Aβ rare and unrelated to GSS development.
Fri Dec 10 00:00:00 EST 2021
Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.
The Journal of biological chemistry
Perdigão C,Barata MA,Burrinha T,Guimas Almeida C
700254 was used in Immunocytochemistry to demonstrate that the LOAD-coding variants in Bin1 lead to a loss of function in endocytic recycling, which may be an early causal mechanism of LOAD.
Wed Sep 01 00:00:00 EDT 2021
Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans.
Human molecular genetics
Benbow SJ,Strovas TJ,Darvas M,Saxton A,Kraemer BC
700254 was used in Luminex to generate a transgenic Caenorhabditis elegans model expressing both human Aβ1-42 peptide and human tau protein pan-neuronally to refine strategies for therapeutic discovery and development for Alzheimer's disease.
Sat Feb 01 00:00:00 EST 2020
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.
EJNMMI research
Pontecorvo MJ,Keene CD,Beach TG,Montine TJ,Arora AK,Devous MD,Navitsky M,Kennedy I,Joshi AD,Lu M,Serrano GE,Sue LI,Intorcia AJ,Rose SE,Wilson A,Hellstern L,Coleman N,Flitter M,Aldea P,Fleisher AS,Mintun MA,Siderowf A
700254 was used in Immunohistochemistry to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.
Mon Jun 15 00:00:00 EDT 2020
Microglial response to experimental periodontitis in a murine model of Alzheimer's disease.
Scientific reports
Kantarci A,Tognoni CM,Yaghmoor W,Marghalani A,Stephens D,Ahn JY,Carreras I,Dedeoglu A
700254 was used in Immunohistochemistry to suggest that microglia is central to the association between PD and AD.
Thu Oct 29 00:00:00 EDT 2020
TREM2 function impedes tau seeding in neuritic plaques.
Nature neuroscience
Leyns CEG,Gratuze M,Narasimhan S,Jain N,Koscal LJ,Jiang H,Manis M,Colonna M,Lee VMY,Ulrich JD,Holtzman DM
700254 was used in Immunohistochemistry to demonstrate a key role for triggering receptor expressed on myeloid cells 2 and microglia in limiting the development of peri-plaque tau pathologies.
Thu Aug 01 00:00:00 EDT 2019
Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease.
Scientific reports
Carreras I,Aytan N,Choi JK,Tognoni CM,Kowall NW,Jenkins BG,Dedeoglu A
700254 was used in Immunohistochemistry to study the effects of fingolimod, a structural analog of sphingosine, and suggests that, unlike the case in multiple sclerosis, fingolimod may potentially have therapeutic benefits in AD at low doses that do not affect peripheral lymphocyte function.
Mon Jul 29 00:00:00 EDT 2019
Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.
Neuron
Eimer WA,Vijaya Kumar DK,Navalpur Shanmugam NK,Rodriguez AS,Mitchell T,Washicosky KJ,György B,Breakefield XO,Tanzi RE,Moir RD
700254 was used in Immunohistochemistry-Immunofluorescence to study the effects of herpesvirus surface glycoproteins on Alzheimer's disease-associated Β-amyloid deposition.
Wed Jul 11 00:00:00 EDT 2018
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.
PloS one
Ilievski V,Zuchowska PK,Green SJ,Toth PT,Ragozzino ME,Le K,Aljewari HW,O'Brien-Simpson NM,Reynolds EC,Watanabe K
700254 was used in Immunohistochemistry-immunofluorescence to study whether repeated exposure of wild type C57BL/6 mice to orally administered porphyromonas gingivalis results in pathognomonic signs of Alzheimer's disease.
Thu Mar 14 00:00:00 EDT 2019
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
The Journal of biological chemistry
Sadleir KR,Popovic J,Vassar R
700254 was used in Dot blot to evaluate whether 5XFAD mice have increased endoplasmic reticulum stress.
Fri Nov 30 00:00:00 EST 2018
Identification of natural products with neuronal and metabolic benefits through autophagy induction.
Autophagy
Fan Y,Wang N,Rocchi A,Zhang W,Vassar R,Zhou Y,He C
700254 was used in dot blot and immunohistochemistry to identify autophagy-inducing phytochemicals
Mon Jan 02 00:00:00 EST 2017
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.
EMBO reports
Ubelmann F,Burrinha T,Salavessa L,Gomes R,Ferreira C,Moreno N,Guimas Almeida C
700254 was used in Immunofluorescence to identify a novel neuron-specific polarisation of beta-amyloid generation controlled by Bin1 and CD2AP.
Sun Jan 01 00:00:00 EST 2017
Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses.
Journal of Alzheimer's disease : JAD
Willén K,Sroka A,Takahashi RH,Gouras GK
700254 was used in Immunocytochemistry-immunoflourescence to demonstrate that AΒ binds to a subset of synapses in cultured neurons, preferentialy to glutamatergic rather than GABAergic neurons.
Mon Apr 09 00:00:00 EDT 2018
The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.
NeuroImage
Badea A,Kane L,Anderson RJ,Qi Y,Foster M,Cofer GP,Medvitz N,Buckley AF,Badea AK,Wetsel WC,Colton CA
700254 was used in immunohistochemistry to propose that the fornix plays a role in Alzheimer's disease
Tue Nov 15 00:00:00 EST 2016
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dinkins MB,Enasko J,Hernandez C,Wang G,Kong J,Helwa I,Liu Y,Terry AV,Bieberich E
700254 was used in ELISA, immunohistochemistry, and western blot to report that reduced exosome secretion due to nSMase2 loss improves pathology and cognition in a mouse model of Alzheimer's disease
Wed Aug 17 00:00:00 EDT 2016
Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
Neurobiology of aging
Perez SE,Sherwood CC,Cranfield MR,Erwin JM,Mudakikwa A,Hof PR,Mufson EJ
700254 was used in immunohistochemistry - free floating to characterize the frontal cortex of wild mountain gorillas (Gorilla beringei beringei) for early Alzheimer's disease-type pathology
Tue Mar 01 00:00:00 EST 2016
Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40.
Brain injury
Lejbman N,Olivera A,Heinzelmann M,Feng R,Yun S,Kim HS,Gill J
700254 was used in ELISA to investigate if amyloid beta 40 or 42 is related to sustaining a traumatic brain injury or to chronic neurological symptoms in a young cohort of military personnel
Wed Jan 03 00:00:00 EST 2018
Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.
Journal of neuropathology and experimental neurology
Postupna N,Keene CD,Crane PK,Gonzalez-Cuyar LF,Sonnen JA,Hewitt J,Rice S,Howard K,Montine KS,Larson EB,Montine TJ
700254 was used in immunohistochemistry - paraffin section to quantify amyloid beta 42 and paired helical filament-tau in the frontal, temporal, and parietal cortices
Sun Feb 01 00:00:00 EST 2015
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.
Neurobiology of aging
Dinkins MB,Dasgupta S,Wang G,Zhu G,Bieberich E
700254 was used in immunohistochemistry to study the role of exosome function in Abeta plaque formation and the therapeutic potential of inhibiting neutral sphingomyelinase-2
Fri Aug 01 00:00:00 EDT 2014
Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's [corrected] disease model.
Nature communications
Wu Z,Guo Z,Gearing M,Chen G
700254 was used in immunocytochemistry to investigate the contribution of GABA inhibition in the dentate gyrus in Alzheimer's disease
Fri Jun 13 00:00:00 EDT 2014
Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause.
Brain : a journal of neurology
Zhang QG,Wang RM,Scott E,Han D,Dong Y,Tu JY,Yang F,Reddy Sareddy G,Vadlamudi RK,Brann DW
700254 was used in immunohistochemistry to study the effects of surgical menopause on the sensitivity of the hippocampal CA3 region to ischemic stress, amyloidogenesis and Abeta42 toxicity
Wed May 01 00:00:00 EDT 2013
Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice.
Cell stress & chaperones
Tóth ME,Szegedi V,Varga E,Juhász G,Horváth J,Borbély E,Csibrány B,Alföldi R,Lénárt N,Penke B,Sántha M
700254 was used in immunohistochemistry to study the beneficial effects of HSP27 overexpression in a murine model of Alzheimer's disease
Fri Nov 01 00:00:00 EDT 2013
Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).
The Journal of comparative neurology
Perez SE,Raghanti MA,Hof PR,Kramer L,Ikonomovic MD,Lacor PN,Erwin JM,Sherwood CC,Mufson EJ
700254 was used in immunohistochemistry to study the pathology of Alzheimer's disease in the western lowland Gorilla
Sun Dec 15 00:00:00 EST 2013
Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans.
PloS one
Zetterberg H,Mörtberg E,Song L,Chang L,Provuncher GK,Patel PP,Ferrell E,Fournier DR,Kan CW,Campbell TG,Meyer R,Rivnak AJ,Pink BA,Minnehan KA,Piech T,Rissin DM,Duffy DC,Rubertsson S,Wilson DH,Blennow K
700254 was used in ELISA to study the effects of hypoxia following cardiac arrest on Abeta42 serum levels in humans
Mon Aug 27 00:00:00 EDT 2012