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Reconstituted by adding 1.0 mL sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20°C.
Inter-species cross-reactivity is a normal feature of antibodies to immunoglobulins and their fragments, since Ig of different species frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail.
In electroimmunodiffusion the amount of antiserum required in the agarose gel is usually about 2% depending on the test arrangement. The amount of beta-thromboglobulin precipitated by 1 mL antiserum is approximately 0.2 mg.
Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). If a slight precipitation occurs upon storage, this should be removed by centrifugation and will not affect the performance of the product. Diluted solutions should be stored at 4°C, not refrozen, and preferably used the same day.
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
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Protein Aliases: beta-thromboglobulin; C-X-C motif chemokine 7; chemokine (C-X-C motif) ligand 7; connective tissue-activating peptide III; CXC chemokine ligand 7; LDGF; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; neutrophil-activating peptide 2; neutrophil-activating peptide-2; PBP; Platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible cytokine B7; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1
Gene Aliases: B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; PPBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
UniProt ID: (Human) P02775
Entrez Gene ID: (Human) 5473
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