Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: LPPVPSSRL GDSWLPRPIP KVPVSAPSSS DPWTGRELTN RHSLPFSLPS QMEPRPDVPR LGSTFSLDTS MSMNSSPLVG PECDHPKIKP SSSANAIYSL AARPLPVPKL PPGEQCEGEE DTEYMTPSSR PLRPLDTSQS SRACDCDQQI DSCTYEAMYN IQSQAPSITE SSTFGEGNLA AAHANTGPEE SENEDDGYDV PKPPVPAVLA RRTLSDISNA SSSFGWLSLD GDPTTNVTEG SQVPERPPKP FPRRINSERK AGSCQQGSGP AASAATASPQ LSSEIENLMS QGYSYQDIQK ALVIAQNNIE MAKNILREFV SISSPAHVAT (578-906 aa encoded by BC132733)
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
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Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
Gene Aliases: C-CBL; CBL; CBL2; FRA11B; NSLL; RNF55
UniProt ID: (Human) P22681
Entrez Gene ID: (Human) 867
Molecular Function: ligase metabolite interconversion enzyme
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