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Product Details
MA5-31053
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
001
Immunogen
Recombinant Mouse c-Met/Met/HGFR Protein (Met1-Asn929)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786710
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse c-Met/Met/HGFR.
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cMet; EC 2.7.10.1; hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; oncogene MET; proto-oncogene c-Met; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Gene Aliases: AI838057; c-Met; HGF; HGFR; Par4
Entrez Gene ID: (Mouse) 17295
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
hepatocyte growth factor-activated receptor activity
protein binding
ATP binding
beta-catenin binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphatase binding
protein complex binding
phospholipase binding
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
transmembrane signal receptor
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
neuron migration
endothelial cell morphogenesis
liver development
placenta development
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
brain development
muscle organ development
skeletal muscle tissue development
positive regulation of gene expression
positive regulation of peptidyl-threonine phosphorylation
negative regulation of peptidyl-threonine phosphorylation
positive regulation of glucose transport
positive regulation of neuron projection development
muscle cell migration
myotube differentiation
phosphorylation
peptidyl-tyrosine phosphorylation
sperm motility
adult behavior
positive regulation of peptidyl-serine phosphorylation
glucose homeostasis
positive regulation of DNA replication
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
hepatocyte growth factor receptor signaling pathway
branching morphogenesis of an epithelial tube
positive regulation of dendrite morphogenesis
modulation of synaptic transmission
positive chemotaxis
myoblast proliferation
excitatory postsynaptic potential
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
semaphorin-plexin signaling pathway
negative regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of endothelial cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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