Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MGSNKSKPK DASQRRRSLE PAENVHGAGG GAFPASQTPS KPASADGHRG PSAAFAPAAA EPKLFGGFNS SDTVTSPQRA GPLAGGVTTF VALYDYESRT ETDLSFKKGE RLQIVNNTEG DWWLAHSLST GQTGYIPSNY VAPSDSIQAE EWYFGKITRR ESERLLLNAE NPRGTFLVRE SETTKGAYCL SVSDFDNAKG LNVKHYKIRK LDSGGFYITS RTQFNSLQQL VAYYSKHADG LCHRLTTVCP TSKPQTQGLA KDAWEIPRES LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER PTFEYLQAFL EDYFTSTEPQ YQPGENL (1-536 aa encoded by BC011566)
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
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Protein Aliases: EC 2.7.10.2; neuronal proto-oncogene tyrosine-protein kinase Src; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; pp60c-src; pp60src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; RP5-823N20.1; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Gene Aliases: ASV; AW259666; c-SRC; p60-Src; pp60c-src; SRC; SRC1; THC6
UniProt ID: (Human) P12931, (Mouse) P05480
Entrez Gene ID: (Human) 6714, (Mouse) 20779
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