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Product Details
PKGA-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 609-659 on human protein kinase G alpha subunit.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1
Gene Aliases: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q5JP05, (Mouse) P0C605
Entrez Gene ID: (Human) 5592, (Mouse) 19091, (Rat) 54286
protein serine/threonine kinase activity
cGMP-dependent protein kinase activity
calcium channel regulator activity
protein binding
ATP binding
cGMP binding
nucleotide binding
catalytic activity
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
mitogen-activated protein kinase p38 binding
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
signal transduction
dendrite development
cGMP-mediated signaling
actin cytoskeleton organization
forebrain development
regulation of GTPase activity
relaxation of vascular smooth muscle
negative regulation of platelet aggregation
mitophagy in response to mitochondrial depolarization
positive regulation of cytosolic calcium ion concentration
metabolic process
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
phosphorylation
positive regulation of circadian rhythm
negative regulation of heart contraction
positive regulation of vasodilation
negative regulation of smooth muscle contraction
cell growth involved in cardiac muscle cell development
positive regulation of large conductance calcium-activated potassium channel activity
regulation of testosterone biosynthetic process
spermatid development
brain development
heart development
cerebellum development
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