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Product Details
66626-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H3F1
Immunogen
cIAP1 Fusion Protein Ag21398 (95-196 aa encoded by BC016174)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LGDSPIQKH KQLYPSCSFI QNLVSASLGS TSKNTSPMRN SFAHSLSPTL EHSSLFSGSY SSLSPNPLNS RAVEDISSSR TNPYSYAMST EEARFLTYHM WPL (95-196 aa encoded by BC016174)
Target Information
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; inhibitor of apoptosis protein; Inhibitor of apoptosis protein 2; mIAP-2; mIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2
Gene Aliases: API1; Api2; AW146227; BIRC2; Birc3; c-IAP1; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; rIAP1; RNF48
UniProt ID: (Human) Q13490, (Mouse) Q62210
Entrez Gene ID: (Human) 329, (Mouse) 11797, (Rat) 60371
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ligase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein N-terminus binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
molecular_function
protease inhibitor
protein polyubiquitination
response to hypoxia
placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular component disassembly involved in execution phase of apoptosis
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of innate immune response
response to ethanol
regulation of cell differentiation
regulation of inflammatory response
protein heterooligomerization
response to cAMP
regulation of cell cycle
regulation of necroptotic process
necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
mitotic spindle assembly
negative regulation of ripoptosome assembly involved in necroptotic process
positive regulation of protein K63-linked ubiquitination
positive regulation of protein K48-linked ubiquitination
positive regulation of protein monoubiquitination
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
regulation of reactive oxygen species metabolic process
apoptotic process
protein ubiquitination
negative regulation of necroptotic process
regulation of nucleic acid-templated transcription
response to organonitrogen compound
response to organic cyclic compound
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