Proteintech

cIAP2 Polyclonal Antibody

cIAP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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cIAP2 Antibody (24304-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 24304-1-AP ( cIAP2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

cIAP2 Antibody in Immunoprecipitation (IP)

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Product Details

24304-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

cIAP2 Fusion Protein Ag20143 (78-169 aa encoded by BC027485)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RGDSPTEKH KKLYPSCRFV QSLNSVNNLE ATSQPTFPSS VTNSTHSLLP GTENSGYFRG SYSNSPSNPV NSRANQDFSA LMRSSYHCAM NNE (78-169 aa encoded by BC027485)

Target Information

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.

Journal of cellular and molecular medicine

Zhang H,Ma B,Li N,Zhang L,Xu J,Zhang S,Guo Z,Han C,Xu S,Li X,Zhang B

Sat Jul 01 00:00:00 EDT 2023

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.

Journal of cancer research and therapeutics

Zhang Y,Chen G,Yan Z,Wang L,Wang D

Thu Sep 01 00:00:00 EDT 2022

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.

Journal of cancer research and therapeutics

Zhang Y,Chen G,Yan Z,Wang L,Wang D

Thu Sep 01 00:00:00 EDT 2022

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.

Journal of cancer research and therapeutics

Zhang Y,Chen G,Yan Z,Wang L,Wang D

Thu Sep 01 00:00:00 EDT 2022

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.

Journal of cancer research and therapeutics

Zhang Y,Chen G,Yan Z,Wang L,Wang D

Thu Sep 01 00:00:00 EDT 2022

The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.

Cell death & disease

Xiang T,Yuan C,Guo X,Wang H,Cai Q,Xiang Y,Luo W,Liu G

Thu Feb 04 00:00:00 EST 2021

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

Cell death & disease

Huangfu J,Hao C,Wei Z,Wormstone IM,Yan H,Fan X

Fri Apr 09 00:00:00 EDT 2021

Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.

Molecular biology reports

Jiang Y,Nan H,Shi N,Hao W,Dong J,Chen H

Mon Mar 01 00:00:00 EST 2021

Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.

Frontiers in oncology

Zhang J,Wang L,Xu X,Li X,Guan W,Meng T,Xu G

Tue Oct 13 00:00:00 EDT 2020

Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang L,Du H,Chen P

Sun Nov 01 00:00:00 EDT 2020

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.

Developmental cell

Zachari M,Gudmundsson SR,Li Z,Manifava M,Cugliandolo F,Shah R,Smith M,Stronge J,Karanasios E,Piunti C,Kishi-Itakura C,Vihinen H,Jokitalo E,Guan JL,Buss F,Smith AM,Walker SA,Eskelinen EL,Ktistakis NT

Mon Sep 09 00:00:00 EDT 2019

Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.

Cancer medicine

Chen SM,Lin TK,Tseng YY,Tu CH,Lui TN,Huang SF,Hsieh LL,Li YY

Wed Aug 01 00:00:00 EDT 2018

Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.

Cancer medicine

Chen SM,Lin TK,Tseng YY,Tu CH,Lui TN,Huang SF,Hsieh LL,Li YY

Wed Aug 01 00:00:00 EDT 2018

The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis.

Oncotarget

Liu TH,Zheng F,Cai MY,Guo L,Lin HX,Chen JW,Liao YJ,Kung HF,Zeng YX,Xie D

Tue May 03 00:00:00 EDT 2016

The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis.

Oncotarget

Liu TH,Zheng F,Cai MY,Guo L,Lin HX,Chen JW,Liao YJ,Kung HF,Zeng YX,Xie D

Tue May 03 00:00:00 EDT 2016

Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.

Biochemical and biophysical research communications

Wu P,Zhu X,Jin W,Hao S,Liu Q,Zhang L

Fri May 01 00:00:00 EDT 2015

Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.

Biochemical and biophysical research communications

Wu P,Zhu X,Jin W,Hao S,Liu Q,Zhang L

Fri May 01 00:00:00 EDT 2015

Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly.

Cancer biology & therapy

Liu Q,Fu H,Xing R,Tie Y,Zhu J,Sun Z,Zheng X

Tue Jul 01 00:00:00 EDT 2008

Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly.

Cancer biology & therapy

Liu Q,Fu H,Xing R,Tie Y,Zhu J,Sun Z,Zheng X

Tue Jul 01 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1

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Gene Aliases: AIP1; API2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49

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UniProt ID: (Human) Q13489

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Entrez Gene ID: (Human) 330

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Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protease inhibitor

Process(es)

apoptotic process cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling spermatogenesis regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein ubiquitination positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of innate immune response regulation of inflammatory response protein heterooligomerization regulation of necroptotic process negative regulation of necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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cIAP2 Polyclonal Antibody

cIAP2 Antibody (24304-1-AP) in IHC (P)

Product Details

24304-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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