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Product Details
PA1-26473
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide surrounding amino acid 510 of human cIAP-2
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.5% BSA, 30% glycerol
Contains
0.01% Thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2259002
Product Specific Information
PA1-26473 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~68 kDa band representing BIRC3 from Jurkat cell lysate
Target Information
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIP 2; API2; apoptosis inhibitor 1; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; mIAP-1; mIAP1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
Gene Aliases: AIP1; Api1; API2; AW107670; Birc2; BIRC3; c-IAP2; cIAP-1; cIAP-2; cIAP1; CIAP2; HAIP1; HIAP1; HIAP2; IAP1; IAP2; MALT2; MIAP1; MIAP2; MIHB; MIHC; RNF49
UniProt ID: (Human) Q13489, (Mouse) O08863
Entrez Gene ID: (Human) 330, (Mouse) 11796, (Rat) 78971
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ligase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protease inhibitor
apoptotic process
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
spermatogenesis
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein ubiquitination
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of innate immune response
regulation of inflammatory response
protein heterooligomerization
regulation of necroptotic process
negative regulation of necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
negative regulation of phosphorylation
necroptotic process
negative regulation of reactive oxygen species metabolic process
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