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Product Details
PA5-29643
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 314 and 538 of Human cIAP2
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547118
Product Specific Information
Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, HeLa WCE, HeLa cytosol, rat spleen.
Predicted reactivity: Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIP 2; API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; H HIAP1; H MALT2; hIAP-1; IAP homolog; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
Gene Aliases: AIP1; API2; Birc2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; IAP1; MALT2; MIHC; RNF49
UniProt ID: (Human) Q13489
Entrez Gene ID: (Human) 330, (Rat) 78971
apoptotic process
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
spermatogenesis
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein ubiquitination
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of innate immune response
regulation of inflammatory response
protein heterooligomerization
regulation of necroptotic process
negative regulation of necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
mitotic spindle assembly
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
negative regulation of phosphorylation
necroptotic process
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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