Proteintech

calreticulin Polyclonal Antibody

calreticulin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 15

calreticulin Antibody (10292-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 10292-1-AP (calreticulin Antibody) at dilution of 1:200 (under 40x lens).

calreticulin Antibody in Western Blot (WB)

calreticulin Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

10292-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 35 publications 35 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 17 publications 17 publications

Flow Cytometry (Flow)

Assay-dependent

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

calreticulin Fusion Protein Ag0325 (1-200 aa encoded by BC002500)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLSVPLLL GLLGLAVAEP AVYFKEQFLD GDGWTSRWIE SKHKSDFGKF VLSSGKFYGD EEKDKGLQTS QDARFYALSA SFEPFSNKGQ TLVVQFTVKH EQNIDCGGGY VKLFPNSLDQ TDMHGDSEYN IMFGPDICGP GTKKVHVIFN YKGKNVLINK DIRCKDDEFT HLYTLIVRPD NTYEVKIDNS QVESGSLEDD W (1-200 aa encoded by BC002500)

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single-center experience.

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Treatment of colon cancer with liver X receptor agonists induces immunogenic cell death.

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Scientific reports

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Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.

Scientific reports

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The international journal of biochemistry & cell biology

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Wang K,Li H,Chen R,Zhang Y,Sun XX,Huang W,Bian H,Chen ZN

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Fri Jul 01 00:00:00 EDT 2016

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

The EMBO journal

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Fri Jul 01 00:00:00 EDT 2016

ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.

International journal of oncology

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ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.

International journal of oncology

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International journal of molecular sciences

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Thu Oct 27 00:00:00 EDT 2016

Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats.

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Fri Mar 01 00:00:00 EST 2013

Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats.

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Yao W,Fan W,Huang C,Zhong H,Chen X,Zhang W

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Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy.

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Proteomic analysis of the differences in orbital protein expression in thyroid orbitopathy.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Cheng KC,Huang HH,Hung CT,Chen CC,Wu WC,Suen JL,Chen KJ,Wu YJ,Chang CH

Sun Dec 01 00:00:00 EST 2013

A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas.

Diagnostic pathology

Yang MS,Wang HS,Wang BS,Li WH,Pang ZF,Zou BK,Zhang X,Shi XT,Mu DB,Zhang DX,Gao YS,Sun XW,Xia SJ

Mon Apr 15 00:00:00 EDT 2013

A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas.

Diagnostic pathology

Yang MS,Wang HS,Wang BS,Li WH,Pang ZF,Zou BK,Zhang X,Shi XT,Mu DB,Zhang DX,Gao YS,Sun XW,Xia SJ

Mon Apr 15 00:00:00 EDT 2013

Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography.

Proteome science

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Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography.

Proteome science

Lu CM,Wu YJ,Chen CC,Hsu JL,Chen JC,Chen JY,Huang CH,Ko YC

Fri Apr 08 00:00:00 EDT 2011

p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.

The Journal of biological chemistry

Deisenroth C,Itahana Y,Tollini L,Jin A,Zhang Y

Fri Aug 12 00:00:00 EDT 2011

p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.

The Journal of biological chemistry

Deisenroth C,Itahana Y,Tollini L,Jin A,Zhang Y

Fri Aug 12 00:00:00 EDT 2011

p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.

The Journal of biological chemistry

Deisenroth C,Itahana Y,Tollini L,Jin A,Zhang Y

Fri Aug 12 00:00:00 EDT 2011

p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.

The Journal of biological chemistry

Deisenroth C,Itahana Y,Tollini L,Jin A,Zhang Y

Fri Aug 12 00:00:00 EDT 2011

Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.

Journal of proteome research

Yang X,Zou P,Yao J,Yun D,Bao H,Du R,Long J,Chen X

Fri Mar 05 00:00:00 EST 2010

Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.

Journal of proteome research

Yang X,Zou P,Yao J,Yun D,Bao H,Du R,Long J,Chen X

Fri Mar 05 00:00:00 EST 2010

Bioinformatics

Protein Aliases: Autoantigen RO; CABP3; CALBP; Calcium-binding protein 3; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)

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Gene Aliases: CALR; Calregulin; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA

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UniProt ID: (Human) P27797, (Mouse) P14211, (Rat) P18418

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Entrez Gene ID: (Human) 811, (Mouse) 12317, (Rat) 64202

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Function(s)

complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding poly(A) RNA binding androgen receptor binding unfolded protein binding chaperone binding metal ion binding chaperone

Process(es)

negative regulation of transcription from RNA polymerase II promoter antigen processing and presentation of peptide antigen via MHC class I peptide antigen assembly with MHC class I protein complex regulation of transcription, DNA-templated protein folding protein export from nucleus cellular calcium ion homeostasis receptor-mediated endocytosis cell cycle arrest spermatogenesis positive regulation of cell proliferation positive regulation of gene expression negative regulation of translation protein maturation by protein folding cortical actin cytoskeleton organization response to estradiol negative regulation of intracellular steroid hormone receptor signaling pathway response to testosterone protein localization to nucleus protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response regulation of meiotic nuclear division response to drug glucocorticoid receptor signaling pathway regulation of apoptotic process negative regulation of neuron differentiation positive regulation of DNA replication positive regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization sequestering of calcium ion cardiac muscle cell differentiation chaperone-mediated protein folding cellular response to lithium ion cellular senescence positive regulation of substrate adhesion-dependent cell spreading positive regulation of dendritic cell chemotaxis response to organic substance cellular response to organic substance

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calreticulin Polyclonal Antibody

calreticulin Antibody (10292-1-AP) in IHC (P)

Product Details

10292-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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