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eIF6 Antibody (A303-029A) in IHC
Detection of human eIF6 by immunohistochemistry. Samples: FFPE serial sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- eIF6 (Cat. No. A303-029A Lot1, left image and Cat. No. A303-030A Lot1, right image) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB. Counterstain: Hematoxylin (blue).
Product Details
A303-029A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 50 and 100 of human Eukaryotic Translation Initiation Factor 6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; p27 beta-4 integrin-binding protein; p27(BBP)
Gene Aliases: b(2)gcn; CAB; eIF-6; EIF3A; EIF6; ITGB4BP; OK/SW-cl.27; p27(BBP); p27BBP
UniProt ID: (Human) P56537
Entrez Gene ID: (Human) 3692
ribosomal subunit export from nucleus
maturation of 5.8S rRNA
maturation of LSU-rRNA
regulation of glycolytic process
translational initiation
response to insulin
gene silencing by miRNA
miRNA mediated inhibition of translation
mature ribosome assembly
regulation of fatty acid biosynthetic process
regulation of megakaryocyte differentiation
positive regulation of translation
assembly of large subunit precursor of preribosome
regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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