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Product Details
GPASW-INS-7S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Swine Insulin
Conjugate
Form
Lyophilized
Concentration
10 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstituted by adding 1 mL sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20°C.
Inter-species cross-reactivity is a normal feature of antibodies to mammalian proteins, since homologous proteins of different species frequently share antigenic determinants. The degree of cross-reactivity is also dependent on the concentRations of the reactants and the sensitivity of the assay arrangement. This antiSerum fraction has not been tested for cross-reactivity.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ins; Insulin; preproinsulin; proinsulin
Gene Aliases: INS
UniProt ID: (Pig) P01315
Entrez Gene ID: (Pig) 397415
negative regulation of acute inflammatory response
glucose metabolic process
regulation of cellular amino acid metabolic process
acute-phase response
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
lipid biosynthetic process
glycoprotein biosynthetic process
positive regulation of nitric oxide mediated signal transduction
positive regulation of glucose metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
lactate biosynthetic process
regulation of transmembrane transporter activity
positive regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase B activity
negative regulation of NAD(P)H oxidase activity
wound healing
lipoprotein biosynthetic process
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of MAPK cascade
negative regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of proteolysis
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
negative regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipid catabolic process
positive regulation of lipoprotein lipase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of protein localization to nucleus
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
response to L-arginine
neuron projection maintenance
negative regulation of feeding behavior
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