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Monoclonal antibody 3 cross reacts with human, mouse and dog l-afadin.
AFDN belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
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Protein Aliases: Afadin; Afadin adherens junction formation factor; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; Protein Af-6
Gene Aliases: Af6; Afdn; Mllt4
UniProt ID: (Rat) O35889
Entrez Gene ID: (Rat) 26955
Molecular Function: non-motor actin binding protein
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