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The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner.
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Protein Aliases: General vesicular transport factor p115; Protein USO1 homolog; TAP; transcytosis associated protein; Transcytosis-associated protein; USO1 vesicle docking protein homolog; VDP p115; vesicle docking protein p115; Vesicle-docking protein
Gene Aliases: P115; TAP; USO1; VDP
UniProt ID: (Human) O60763
Entrez Gene ID: (Human) 8615
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