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FIGURE: 1 / 4
Positive Control: mouse brain, rat brain, rat testis
Predicted Reactivity: Mouse (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BCA1; Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; OTTHUMP00000174941; p130 Cas; p130cas; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; v-crk-associated tyrosine kinase substrate
Gene Aliases: AI385681; Bcar1; Cas; Crkas; P130CAS
UniProt ID: (Mouse) Q61140, (Rat) Q63767
Entrez Gene ID: (Mouse) 12927, (Rat) 25414
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