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Product Details
MA5-38139
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1986
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human P23/PTGES3 (NP_0065923)
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898057
Product Specific Information
Positive Samples: Rat testis, Rat brain, HeLa, HepG2, Jurkat, Mouse testis, Mouse brain
Immunogen sequence: MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Co chaperone p23; cPGES; cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; p23 cochaperone; Progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; ptges3 {ECO:0000250|UniProtKB:Q15185}; Sid 3177; telomerase binding protein, p23; Telomerase-binding protein p23; unactive progesterone receptor, 23 kD
Gene Aliases: 5730442A20Rik; cPGES; P23; Ptges; PTGES3; RGD1561913; Sid3177; TEBP
UniProt ID: (Human) Q15185, (Rat) P83868, (Mouse) Q9R0Q7
Entrez Gene ID: (Human) 10728, (Rat) 362809, (Mouse) 56351
telomere maintenance
prostaglandin biosynthetic process
RNA-dependent DNA biosynthetic process
signal transduction
cyclooxygenase pathway
chaperone cofactor-dependent protein refolding
regulation of cellular response to heat
glycogen biosynthetic process
prostaglandin metabolic process
cell proliferation
positive regulation of gene expression
sensory perception of pain
glucocorticoid receptor signaling pathway
skin development
lung saccule development
negative regulation of cell death
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
DNA biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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