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Search Thermo Fisher Scientific
The antibody detects a 41 kDa* protein corresponding to the molecular mass of Arpc1b on SDS-PAGE immunoblots of human A431 and Jurkat cells, rat A7r5 and PC12 cells, and mouse C2C12 cells.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: actin related protein 2/3 complex subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B, 41kDa; Actin-related protein 2/3 complex subunit 1B; Actin-related protein complex 1b; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; OTTHUMP00000206020; p41-ARC
Gene Aliases: 41kDa; AA408064; AA408534; AA571392; AF007010; ARC41; ARPC1B; AW208418; L72; p40-ARC; p41-ARC; SOP2Hs
UniProt ID: (Human) O15143, (Rat) O88656, (Mouse) Q9WV32
Entrez Gene ID: (Human) 10095, (Rat) 54227, (Mouse) 11867
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