p53 Monoclonal Antibody (PAb 240)

RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protease binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding copper ion binding protein binding ATP binding transcription factor binding zinc ion binding enzyme binding protein kinase binding protein phosphatase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding protein self-association transcription regulatory region DNA binding protein heterodimerization activity protein N-terminus binding chaperone binding protein phosphatase 2A binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription cofactor binding protein C-terminus binding histone deacetylase regulator activity MDM2/MDM4 family protein binding metal ion binding P53-like transcription factor

negative regulation of transcription from RNA polymerase II promoter DNA strand renaturation base-excision repair nucleotide-excision repair regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein complex assembly cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ER overload response cell cycle arrest Ras protein signal transduction multicellular organism development cell aging protein localization cell proliferation negative regulation of cell proliferation determination of adult lifespan response to X-ray response to gamma radiation positive regulation of gene expression viral process protein sumoylation cell differentiation negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator positive regulation of histone deacetylation chromatin assembly mitotic G1 DNA damage checkpoint positive regulation of protein oligomerization cellular response to UV cellular response to drug cellular response to glucose starvation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to antibiotic positive regulation of protein export from nucleus regulation of mitochondrial membrane permeability negative regulation of fibroblast proliferation circadian behavior positive regulation of peptidyl-tyrosine phosphorylation negative regulation of helicase activity protein tetramerization negative regulation of telomerase activity positive regulation of thymocyte apoptotic process positive regulation of cell cycle arrest cellular response to hypoxia cellular response to ionizing radiation intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of release of cytochrome c from mitochondria replicative senescence oxidative stress-induced premature senescence intrinsic apoptotic signaling pathway oligodendrocyte apoptotic process positive regulation of execution phase of apoptosis positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator regulation of cell cycle G2/M phase transition positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of reactive oxygen species metabolic process positive regulation of intrinsic apoptotic signaling pathway protein import into nucleus, translocation in utero embryonic development somitogenesis release of cytochrome c from mitochondria T cell proliferation involved in immune response B cell lineage commitment T cell lineage commitment positive regulation of leukocyte migration response to ischemia double-strand break repair regulation of transcription from RNA polymerase II promoter apoptotic process response to oxidative stress transforming growth factor beta receptor signaling pathway gastrulation negative regulation of neuroblast proliferation central nervous system development aging negative regulation of DNA replication rRNA transcription response to UV response to salt stress embryo development ending in birth or egg hatching response to inorganic substance response to metal ion response to UV-B response to organonitrogen compound positive regulation of cardiac muscle cell apoptotic process response to organic cyclic compound cerebellum development negative regulation of transforming growth factor beta receptor signaling pathway response to caffeine response to retinoic acid T cell differentiation in thymus response to vitamin B3 response to cytokine regulation of tissue remodeling cellular response to heat cellular protein localization multicellular organism growth positive regulation of mitochondrial membrane permeability wound healing regulation of cell proliferation response to drug response to amino acid mitochondrial DNA repair regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of proteolysis negative regulation of mitotic cell cycle embryonic organ development negative regulation of smooth muscle cell proliferation regulation of catalytic activity chromosome organization neuron apoptotic process regulation of intracellular pH regulation of cell cycle response to hyperoxia regulation of thymocyte apoptotic process necroptotic process cellular response to organonitrogen compound mitotic cell cycle arrest positive regulation of cell aging negative regulation of macromitophagy regulation of mitochondrial membrane permeability involved in apoptotic process regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of hydrogen peroxide-induced cell death regulation of fibroblast apoptotic process negative regulation of DNA biosynthetic process negative regulation of reactive oxygen species metabolic process regulation of cellular senescence transcription, DNA-templated cell cycle programmed cell death chromosome breakage rhythmic process positive regulation of transcription from RNA polymerase II promoter in response to hypoxia intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to UV-C regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose catabolic process to lactate via pyruvate intrinsic apoptotic signaling pathway in response to hypoxia