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Invitrogen
pro-Brain Natriuretic Peptide Monoclonal Antibody (5B6)
FIGURE: 1 / 2
pro-Brain Natriuretic Peptide Antibody (MA1-20622) in WB
Detection of human recombinant proBNP expressed mammalian cells in Western blotting by different monoclonal antibodies after Tricine-SDS gel electrophoresis. Antigen: recombinant proBNP expressed in mammalian cells, 0.15 ug; Lane 1: pro-Brain Natriuretic Peptide Monoclonal Antibody (5B6) (Product # MA1-20622); Lane 2: pro-Brain Natriuretic Peptide Monoclonal Antibody (15F11) (Product # MA1-20626); Lane 3: p... View More
Product Details
MA1-20622
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5B6
Immunogen
Synthetic peptide corresponding to residues H(1) P L G S P G S A S D L(12) of human proBNP.
Conjugate
Form
Liquid
Concentration
5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_560693
Product Specific Information
MA1-20622 detects proBNP in human samples.
Target Information
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BNP32; Brain natriuretic factor prohormone; brain type natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; Natriuretic peptides B; natriuretic protein; NTproBNP; preproBNP
Gene Aliases: BNP; NPPB
UniProt ID: (Human) P16860
Entrez Gene ID: (Human) 4879
cGMP biosynthetic process
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vasodilation
regulation of vascular permeability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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