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Product Details
PBNP-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within aino acid region 100-150 on human proBNP protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BNP32; Brain natriuretic factor; Brain natriuretic factor prohormone; brain natriuretic peptide; brain type natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; Natriuretic peptides B; natriuretic protein; NTproBNP; preproBNP; type-B natriuretic factor
Gene Aliases: AA408272; BNF; BNP; NPPB
UniProt ID: (Human) P16860, (Rat) P13205, (Mouse) P40753
Entrez Gene ID: (Human) 4879, (Rat) 25105, (Mouse) 18158
response to hypoxia
negative regulation of systemic arterial blood pressure
cGMP biosynthetic process
inflammatory response
receptor guanylyl cyclase signaling pathway
heart development
regulation of blood pressure
response to organic cyclic compound
negative regulation of cell growth
response to lipopolysaccharide
positive regulation of urine volume
positive regulation of renal sodium excretion
response to drug
response to peptide hormone
negative regulation of smooth muscle cell proliferation
regulation of blood vessel size
response to calcium ion
cellular response to mechanical stimulus
positive regulation of collecting lymphatic vessel constriction
cell surface receptor signaling pathway
body fluid secretion
negative regulation of angiogenesis
regulation of vasodilation
regulation of vascular permeability
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