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transgelin/SM22 Monoclonal Antibody (2A10C2)

transgelin/SM22 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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transgelin/SM22 Antibody (60213-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon tissue slide using 60213-1-Ig (transgelin/SM22 antibody) at dilution of 1:200 (under 40x lens).

transgelin/SM22 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

transgelin/SM22 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

60213-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:400

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 6 publications 6 publications

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2A10C2

Immunogen

transgelin/SM22 Fusion Protein Ag0764 (1-201 aa encoded by BC004927)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MANKGPSYG MSREVQSKIE KKYDEELEER LVEWIIVQCG PDVGRPDRGR LGFQVWLKNG VILSKLVNSL YPDGSKPVKV PENPPSMVFK QMEQVAQFLK AAEDYGVIKT DMFQTVDLFE GKDMAAVQRT LMALGSLAVT KNDGHYRGDP NWFMKKAQEH KREFTESQLQ EGKHVIGLQM GSNRGASQAG MTGYGRPRQI IS (1-201 aa encoded by BC004927)

Target Information

TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling.

Journal of ethnopharmacology

Zou X,Huang Z,Zhan Z,Yuan M,Zhang Y,Liu T,Hu X,Fan W,Chen P,Qin H,Zhang S,Xia Y,Zheng S,Pan Z,Huang P

Fri Sep 15 00:00:00 EDT 2023

Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats.

Clinical and experimental pharmacology & physiology

Liu L,Yang H,Kuang SJ,Zhang L,Zhou MY,Zeng P,Zhang MZ,Rao F,Zhou ZL,Deng CY

Wed Feb 01 00:00:00 EST 2023

Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.

BMC medical genomics

Peng Z,Wang K,Wang S,Wu R,Yao C

Sat Jun 17 00:00:00 EDT 2023

LDHA mediated degradation of extracellular matrix is a potential target for the treatment of aortic dissection.

Pharmacological research

Wu X,Ye J,Cai W,Yang X,Zou Q,Lin J,Zheng H,Wang C,Chen L,Li Y

Tue Feb 01 00:00:00 EST 2022

Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ.

Biochimica et biophysica acta. Molecular basis of disease

Luo BY,Zhou J,Guo D,Yang Q,Tian Q,Cai DP,Zhou RM,Xu ZZ,Wang HJ,Chen SY,Xie WB

Thu Sep 01 00:00:00 EDT 2022

The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene.

Evidence-based complementary and alternative medicine : eCAM

Wei W,Zhou YJ,Shen JL,Lu L,Lv XR,Lu TT,Xu PT,Xue XH

Tue Jul 19 00:00:00 EDT 2022

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling.

Frontiers in cell and developmental biology

Liu JT,Bao H,Fan YJ,Li ZT,Yao QP,Han Y,Zhang ML,Jiang ZL,Qi YX

Tue Oct 05 00:00:00 EDT 2021

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells.

Frontiers in cardiovascular medicine

Zheng H,Qiu Z,Chai T,He J,Zhang Y,Wang C,Ye J,Wu X,Li Y,Zhang L,Chen L

Sun May 01 00:00:00 EDT 2022

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells.

Frontiers in cardiovascular medicine

Zheng H,Qiu Z,Chai T,He J,Zhang Y,Wang C,Ye J,Wu X,Li Y,Zhang L,Chen L

Sun May 01 00:00:00 EDT 2022

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells.

Frontiers in cardiovascular medicine

Zheng H,Qiu Z,Chai T,He J,Zhang Y,Wang C,Ye J,Wu X,Li Y,Zhang L,Chen L

Sun May 01 00:00:00 EDT 2022

Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells.

Frontiers in cardiovascular medicine

Zheng H,Qiu Z,Chai T,He J,Zhang Y,Wang C,Ye J,Wu X,Li Y,Zhang L,Chen L

Sun May 01 00:00:00 EDT 2022

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Asian journal of andrology

Yue XF,Shen CX,Wang JW,Dai LY,Fang Q,Long L,Zhi Y,Li XR,Wang YW,Shen GF,Liu ZJ,Shi CM,Li WB

Fri Dec 03 00:00:00 EST 2021

The near-infrared dye IR-61 restores erectile function in a streptozotocin-induced diabetes model via mitochondrial protection.

Asian journal of andrology

Yue XF,Shen CX,Wang JW,Dai LY,Fang Q,Long L,Zhi Y,Li XR,Wang YW,Shen GF,Liu ZJ,Shi CM,Li WB

Fri Dec 03 00:00:00 EST 2021

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition.

Cells

Goikuria H,Freijo MDM,Vega Manrique R,Sastre M,Elizagaray E,Lorenzo A,Vandenbroeck K,Alloza I

Sun Mar 18 00:00:00 EDT 2018

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition.

Cells

Goikuria H,Freijo MDM,Vega Manrique R,Sastre M,Elizagaray E,Lorenzo A,Vandenbroeck K,Alloza I

Sun Mar 18 00:00:00 EDT 2018

Specific role of RhoC in tumor invasion and metastasis.

Oncotarget

Lang S,Busch H,Boerries M,Brummer T,Timme S,Lassmann S,Aktories K,Schmidt G

Fri Oct 20 00:00:00 EDT 2017

Specific role of RhoC in tumor invasion and metastasis.

Oncotarget

Lang S,Busch H,Boerries M,Brummer T,Timme S,Lassmann S,Aktories K,Schmidt G

Fri Oct 20 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: 22 kDa actin-binding protein; Actin-associated protein p27; DKFZp686B01212; DKFZp686P11128; Protein WS3-10; sm22 alpha; SM22-alpha; Sm22alpha; smooth muscle 22 protein; Smooth muscle protein 22-alpha; Transgelin; transgelin variant 2

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Gene Aliases: SM22; SM22A; SMCC; TAGLN; TAGLN1; WS3-10; Ws310

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UniProt ID: (Human) Q01995, (Rat) P31232, (Mouse) P37804

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Entrez Gene ID: (Human) 6876, (Pig) 397021, (Rat) 25123, (Mouse) 21345

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Function(s)

actin binding protein binding protein binding, bridging actin filament binding non-motor actin binding protein

Process(es)

muscle organ development epithelial cell differentiation cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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transgelin/SM22 Monoclonal Antibody (2A10C2)

transgelin/SM22 Antibody (60213-1-IG) in IHC (P)

Product Details

60213-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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