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Comprehensive solutions for characterization, confirmation, and monitoring of your vaccine

Thermo Fisher Scientific is your trusted partner to help ensure your vaccine quality with speed at every stage of the development process – from discovery to commercial production – so that you can go to market quickly and confidently.

Use our proven portfolio of comprehensive analytical solutions for characterization, confirmation, and monitoring—whether you are working on a whole inactivated, live attenuated, protein based, virus-like particle (VLP), mRNA, viral vector, or non-viral vector DNA vaccines. The analytical approaches for different types of vaccines are provided in these pages. 

Biomolecule separations

HPLC Systems

Charge Aerosol Detection

IC Systems

Mass Spectrometry

Chromatography Data Systems

BioLC Columns
BioLC Columns

Vanquish Horizon
Vanquish Horizon
and
Vanquish Flex UHPLC Systems

Vanquish Charged Aerosol Detectors (CAD)
Vanquish Charged Aerosol Detectors (CAD)

 

Ion Chromatography (IC) Systems

Ion Chromatography (IC) Systems		Orbitrap Exploris Mass Spectrometer

Orbitrap Exploris Mass Spectrometer		Chromeleon 7.3 CDS

Chromeleon 7.3 CDS

Characterize the full diversity of your vaccine biomolecules

Get high resolution, high efficiency separation of your vaccine associated biological samples. Our unique column chemistries for biological samples have been specifically designed for the separation of proteins, peptides, monoclonal antibodies, carbohydrates, nucleic acids, and more.

Accelerate your vaccine development with confidence

Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced liquid chromatography instruments available. The Vanquish LC platform improves performance, repeatability, and dependability with no trade-offs in quality or ease-of-use. Vanquish LC systems provide the versatility to solve the toughest vaccine analytics challenges.

Ensuring the safety of your final vaccine products

A highly flexible Thermo Scientific Dionex ion chromatography (IC) system provides customers with the freedom to develop, explore, and run different methods simultaneously. Utilizing unique IC technologies with unparalleled robustness and capabilities, one can accurately identify and monitor formulation and process residual components and ensure appropriate adjuvant concentrations, with ease.

Universal detection and quantification for non-chromophore containing adjuvants and formulations

Utilize the increased separation speed and resolution of the Thermo Scientific Vanquish UHPLC system with charged aerosol detection (CAD). CAD can detect and quantify virtually any substance with enhanced linear dynamic range and accurate, consistent response. Measure low-level impurities and active pharmaceutical ingredients (APIs) simultaneously, as well as other compounds, regardless of chemical structure using CAD.

Comprehensive vaccine characterization

Thermo Scientific Orbitrap Exploris mass spectrometry system is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation of vaccine products. Extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements, deliver comprehensive characterization of your most advanced vaccine drug products, and accelerate their development.

The Expanding Role of Mass Spectrometry in the Field of Vaccine Development 

Track everything, simplify compliance, and boost productivity

Achieve productivity and compliance with one software platform. As an integral part of your laboratory's IT structure, the latest Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) is vital for compliant, efficient, and reliable handling of today’s chromatography and mass spectrometry data. It ensures data quality and manages all the analytical processes from instrument control, to raw data storage and processing, to generating the final results.

Characterize the full diversity

Characterize the full diversity of your vaccine biomolecules

Get high resolution, high efficiency separation of your vaccine associated biological samples. Our unique column chemistries for biological samples have been specifically designed for the separation of proteins, peptides, monoclonal antibodies, carbohydrates, nucleic acids, and more.

Accelerate your vaccine development

Accelerate your vaccine development with confidence

Thermo Scientific Vanquish HPLC and UHPLC systems are the most advanced liquid chromatography instruments available. The Vanquish LC platform improves performance, repeatability, and dependability with no trade-offs in quality or ease-of-use. Vanquish LC systems provide the versatility to solve the toughest vaccine analytics challenges.

Ensuring the safety

Ensuring the safety of your final vaccine products

A highly flexible Thermo Scientific Dionex ion chromatography (IC) system provides customers with the freedom to develop, explore, and run different methods simultaneously. Utilizing unique IC technologies with unparalleled robustness and capabilities, one can accurately identify and monitor formulation and process residual components and ensure appropriate adjuvant concentrations, with ease.

Universal detection and quantification

Universal detection and quantification for non-chromophore containing adjuvants and formulations

Utilize the increased separation speed and resolution of the Thermo Scientific Vanquish UHPLC system with charged aerosol detection (CAD). CAD can detect and quantify virtually any substance with enhanced linear dynamic range and accurate, consistent response. Measure low-level impurities and active pharmaceutical ingredients (APIs) simultaneously, as well as other compounds, regardless of chemical structure using CAD.

Comprehensive vaccine characterization

Comprehensive vaccine characterization

Thermo Scientific Orbitrap Exploris mass spectrometry system is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation of vaccine products. Extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements, deliver comprehensive characterization of your most advanced vaccine drug products, and accelerate their development.

The Expanding Role of Mass Spectrometry in the Field of Vaccine Development 

Track everything, simplify compliance

Track everything, simplify compliance, and boost productivity

Achieve productivity and compliance with one software platform. As an integral part of your laboratory's IT structure, the latest Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) is vital for compliant, efficient, and reliable handling of today’s chromatography and mass spectrometry data. It ensures data quality and manages all the analytical processes from instrument control, to raw data storage and processing, to generating the final results.

Select the type of vaccine below to review the recommended analytical workflows for your vaccine.

Protein Vaccines

  • Robust Charge Variant Profiling
  • Glycan Profiling
  • Intact Glycoform Analysis
  • Glycopeptide Workflow
  • Peptide Mapping
  • Residual Host Cell Protein Analysis (HCPs)
  • Peptide Mapping for QC/Lot release
  • Release Glycan Monitoring    

Sign up to attend workshops of interest

  • BioPharma Finder software for characterization of protein and oligonucleotide biotherapeutics
  • BioPharma Finder software for in-depth protein characterization, intact mass analysis, peptide mapping, and new host cell protein workflow
  • BioPharma Finder software for in-depth oligonucleotide characterization with intact mass analysis, oligonucleotide analysis, and mRNA mapping
  • GlycanExplorer software for high throughput biotherapeutic glycan characterization
  • Proteome Discoverer software for increasing proteoform level insight with quantitative top-down proteomics

Attend virtual workshops

Style Sheet for Global Design System
Style Sheet for Komodo Tabs