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Overview
Targeted protein quantitation with mass spectrometry plays an important role in developing therapeutic strategies, vaccine development, variant detection, virology, and disease pathogenesis.
Disease and disorders research helps us understand proteomic, metabolomic, lipidomic, or genomic profiles in the presence of the virus/disease; monitoring therapeutic influence for potential biomarkers, and monitoring critical and targeted viral and/or human plasma proteins to determine and predict the extent of infection.
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LC-MS enables accurate targeted protein quantitation in disease research
Featured instruments and software
Vanquish Horizon UHPLC
The Thermo Scientific Vanquish Horizon UHPLC offers superior separations, detector sensitivity and lower baseline noise.
TSQ Altis Plus Triple Quadrupole MS
The Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer redefines performance.
Orbitrap Exploris 240 MS
Application flexibility and the performance to drive discovery. Deliver on objectives with the Thermo Scientific Orbitrap Exploris 240 mass spectrometer.
Software and data management
Accelerate discoveries and streamline operations. Acquire, analyze, and manage data with innovative software.
Disease and disorders resources
Explore our applications, technical notes, case studies as well as peer-reviewed articles.
Infectious diseases, including SARS-CoV-2 (COVID-19)
For research in infectious diseases, including the study of viral antigens and nucleic acids and detection of virus-specific antibodies in blood samples, liquid chromatography (LC) coupled to mass spectrometry (MS) technology can achieve and deliver outstanding confidence in results. Mass spectrometry (MS) provides insights into viral behavior by studying intact viral particles as well as their surfaces and binding characteristics, protein compositions, and their impacts on the biochemical pathways of host cells upon infection.
Reducing SARS-CoV-2 false positives using LC-MS
LC-MS for detecting SARS-CoV-2 viral and host proteins
Inborn errors of metabolism (IEM)
LC-MS facilitates prompt identification and treatment for newborn genetic and metabolic disorder screenings.
Analyze amino acids, acylcarnitines, and succinylacetone
Amino acids and acylcarnitines quantitation
Amino acid, acylcarnitine, succinylacetone, argininosuccinic acid quanititation
MS for amino acids, acylcarnitines, and succinylacetone analysis
Cancer identification
Real-time cancerous tissue identification: MasSpec Pen in the hands of surgeons
Accuracy and identification of biomarkers are pivotal to diagnosing and treating cancer. LC-MS provides flexibility in cancer research and allows for in vivo identification of tissue in clinical settings.
Breath biopsy for early disease detection
In collaboration with Owlstone Medical, the development of a non-invasive Breath Biopsy approach for disease detection is underway to enable early disease detection through discovery of novel biomarkers using Thermo Scientific TD-GC-Orbitrap mass spectrometry technology. Compared to genomics and other -omics approaches, studying breath VOCs, so-called 'breathomics,' reveals the current health status of cells, tissues, and the microbiome.
Breath Biopsy for non-invasive disease detection - Billy Boyle, of Owlstone Medical
Breath Biopsy with TD-GC-Orbitrap: a non-invasive approach for disease detection
Additional research on important diseases
In orphan disease, diabetes, tuberculosis (TB), and Zika, LC-MS is playing a pivotal role in focusing on expression of critical proteomes responding to infection, monitoring proteoform distribution by comparison, and identifying critical peptides that are unique to infected individuals.
Automated High-Throughput Data Processing for Targeted Multiplexed Insulin Analog Detection and Quantification
Explore peer reviewed articles, showing how LC-MS plays a role in understanding disease.
Monitoring Antiretrovirals Using High-Resolution Mass Spectrometry
Customer review — Mass spectrometry in the hands of surgeons
" Orbitrap Exploris series mass spectrometers provide high resolution and mass accuracy as well as consistent reproducibility and operational simplicity with a compact footprint.
This enables easier integration into clinical settings that otherwise would not be able to house a mass spectrometer, such as an operating room, making it an ideal mass spectrometer to pair with the MasSpec Pen."
— Livia S. Eberlin, Ph.D.
Associate Professor, Baylor College of Medicine
Co-Founder & Chief Scientific Officer, MS Pen Technologies
Additional clinical research topics and resources
MS for clinical research
Need to monitor drugs for immunosuppressants, investigate potential biomarkers for disease targets, or measuring the output of endocrine glands?
MS for clinical translational research
Analyzing complex biological samples such as plasma, serum, whole blood, urine, sputum, cerebrospinal fluid (CSF), and oral fluid?
Speak to an expert about mass spectrometry solutions for disease and disorders
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Style Sheet for Komodo Tabs