Biomolecule HPLC and UHPLC Columns

Overview

See your biotherapeutics in high resolution

Analysis of biopharmaceutical therapeutic products demands the use of high quality HPLC and UHPLC columns to achieve high quality results. As leaders of innovative, reliable HPLC and UHPLC column development for over 40 years, you can trust Thermo Scientific columns to meet your needs for complex separations and analyses. Our columns for biomolecule separation – referred to as BioLC columns – were designed for high resolution, enhanced sensitivity, faster analyses, and consistent performance. Browse our recommended columns for your applications below.

Recommended HPLC/UHPLC columns for biomolecules


HIC HPLC columns for Intact Mass Analysis	SEC HPLC columns for Aggregate Analysis	Charge Variant Analysis HPLC columns	Oligonucleotide HPLC & UHPLC columns
Separate neutral mAbs from their aggregates based on hydrophobicity Hydrophobic interaction chromatography (HIC)	Monitor mAb aggregates by their size Size-exclusion chromatography (SEC)	Detect therapeutic protein modifications Charge variant analysis by ion-exchange chromatography (IEC)	Separate oligonucleotide and nucleic acid mixtures including siRNA and mRNA Anion-exchange and reversed phase (RP) column chemistries
MAbPac HIC-10 MAbPac HIC-20 MAbPac HIC-Butyl	MAbPac SEC-1 Acclaim SEC-300 Acclaim SEC-1000	ProPac Elite WCX ProPac 3R SCX ProPac 3R SAX CX-1 pH Buffers	DNAPac RP DNAPac PA200(RS) DNASwift
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HPLC Columns for Intact Mass & Subunit Analysis	Affinity Chromatography HPLC Columns	HPLC & UHPLC Columns for Peptide Mapping & MAM	HILIC HPLC Columns for Glycan Analysis
Ideal for intact protein and subunit analysis Reversed phase (RP) chromatography	Purify mAbs, mRNA, and AAV gene therapeutics Affinity chromatography	Perform peptide mapping and Multi-Attribute Methods (MAM) Reversed phase (RP) chromatography	Perform glycan analysis of neutral monoclonal antibodies and proteins Hydrophilic interaction liquid chromatography (HILIC)
MAbPac RP	MAbPac Protein A	Hypersil GOLD Vanquish C18 UHPLC Accucore Vanquish C18+	Accucore 150 Amide HILIC