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Accelerate and automate your method development using Thermo Scientific Vanquish Method Development HPLC and UHPLC systems. These systems can optimize separation conditions by testing different combinations of buffers on up to six HPLC columns. Vanquish Method Development HPLC and UHPLC systems use Thermo Scientific Chromeleon Chromatography Data System (CDS), which features downloadable eWorkflows to simplify automated column and buffer scouting while enabling secure and central data storage. Achieve fully automated method development with ChromSwordAuto Chromeleon Connect and ChromSword AutoRobust Chromeleon Connect. Chromeleon CDS is also compatible with the S-Matrix® Fusion QbD® software package.
Automated column and eluent screening option
Screen up to 13 eluents by equipping your Vanquish Method Development HPLC and UHPLC system with a solvent selection valve for extensive, automated screening. The Thermo Scientific Viper Method Scouting Kit contains all the tubing and near-zero dead volume connections to screen four columns automatically without the need for any user interaction.
Universal and sensitive detection techniques
Detect all non- or semi-volatile analytes using a near-universal Thermo Scientific Charged Aerosol Detector. Additionally, gain more confidence in identification using the Thermo Scientific ISQ EC and EM single quadrupole mass detectors for peak identification and impurity profiling.
Automated, software-assisted method development
Automate, simplify and accelerate method development. The Vanquish Method Development HPLC and UHPLC systems are controlled by Chromeleon CDS and compatible with leading method development software packages, such as ChromSwordAuto Chromeleon Connect or Fusion QbD software.
Secure data storage
The Chromeleon Data Vault ensures secure data storage and accessibility for users within the CDS infrastructure. With Vanquish Method Development HPLC and UHPLC systems, all data generated is safely backed up in Chromeleon CDS Data Vault, enabling easy data exchange throughout the organization.
Optimized for small and large molecules
When built using Vanquish Flex and Vanquish Horizon UHPLC components, these systems are biocompatible, enabling robust performance, even with high-salt gradients, while minimizing unwanted interactions between the analyte and system components. ChromSwordAuto Chromeleon Connect includes dedicated algorithms for more efficient separations of large biomolecules.
Method validation
Automate design and execution of robustness testing using ChromSword AutoRobust Chromeleon Connect and accelerate your method validation using the workflows available in the Chromeleon 7 Extension Pack ICH templates.
The table below provides an overview of the system specifications for the Vanquish Method Development HPLC and UHPLC systems for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.
Category |
Vanquish Method Development HPLC and UHPLC Systems |
System pressure, maximum |
700, 1000 or 1500 bar, depends on system configuration |
Flow range |
0-5, 0-8 or 0-10 mL/min, depends on pumps selected |
Pump options (default delay volume) |
Binary (35, 200 or 400 µL) Quaternary (679 µL) Dual (679 µL) Isocratic Delay volume depends on pump(s) selected |
Biocompatible |
Yes, depends on system configuration |
pH range |
2-12, chloride concentration up to 1 mol/L or 1-13 (chloride concentration up to 0.1 mol/L), depends on system configuration |
System design |
Modular |
Touchscreen user interface display compatible (optional) |
Yes, depends on system configuration |
Solvent monitoring system compatible (optional) |
Yes, depends on system configuration |
Customizable gradient delay volume to simplify method transfer |
Yes, depends on system configuration |
SmartInject technology for maximum injection precision and improved column lifetime |
Yes |
Injection volume range |
Standard: 0.01-25 or 0.01-100 µL (Vanquish Flex/Vanquish Horizon) Optional: Up to 0.01-100 or 0.01-1000 µL (Vanquish Core) Depends on sampler selected |
Sample cooling |
Yes, 4-40°C Depends on sampler selected |
Sample capacity (standard) Based on standard 12 mm OD vials (≤ 1.5 mL) |
4 racks of 54 vials (≤ 1.5mL) each, other rack formats available |
Sampler extension available |
Yes, with Vanquish Charger |
Column compartment thermostatting |
Yes, 5-120°C, depends on column compartment selected Still air and forced air |
Column compartment pre-heater |
Active and passive |
Column compartment post-column cooler |
Yes Depends on column compartment selected |
Detector choices |
Vanquish Charged Aerosol Detector Vanquish Diode array Detector Vanquish Fluorescence Detector Vanquish Multiple Wavelength Detector Vanquish Variable Wavelength Detector Refractive Index Detector Mass Spectrometer |
Standard Vanquish Method Development HPLC and UHPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component.
|
Vanquish Horizon Method Development UHPLC System |
Vanquish Flex Method Development UHPLC System |
Vanquish Core Method Development HPLC System |
Pump |
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Autosampler |
or |
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Extended sample capacity (optional) |
Vanquish Charger |
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Column compartment |
Up to 3 Vanquish Column Compartment H or Up to 3 Vanquish Column Compartment C |
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Virtually zero dead volume system connections - Method scouting capabilities |
Automated Viper Method Scouting kit for Vanquish Systems (6036.2807) + 2 x Valve 6 position 7 port (6036.1570) |
Automated Viper Method Scouting kit for Vanquish Systems (6036.2807) + 2 x Valve 6 position 7 port (6230.1530) |
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Virtually zero dead volume system connections - Eluent scouting capabilities |
Extension kit for Automated Method Scouting (6036.0100) |
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Detectors |
ChromSword is a trademark of VWR International BVBA. S-Matrix and Fusion QbD are trademarks of S-Matrix Corporation.
For Research Use Only. Not for use in diagnostic procedures.