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Highlights
Advanced instrument control software, compound database integration, and predefined method templates simplify operations, enabling LC-MS/MS users of all skill sets to obtain high-confidence data.
Achieve next-level productivity, versatility, and performance for method development and routine sample analysis. The Thermo Scientific TSQ Quantis Plus triple quadrupole mass spectrometer combines enhanced acquisition speed and sensitivity with proven robustness and reliability to deliver confident targeted screening and quantitation for high-throughput applications.
Explore next-level productivity with the TSQ Plus mass spectrometer portfolio tour
Reducing the barrier to productivity: Operational simplicity
Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Predefined method templates with integration to databases, including the Thermo Scientific mzCloud database, enable targeted quantitation method creation based on empirical knowledge. Also, direct method transfer from previous Thermo Scientific TSQ Quantis mass spectrometers can be loaded and operated without optimization.
Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.
Speed with selectivity and sensitivity
Achieve superior acquisition speeds on the TSQ Quantis Plus mass spectrometer, which can acquire 600 SRMs/sec and when combined with a new power supply enables 5 ms polarity switching and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.
The TSQ Quantis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active Q2 collision cell improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.
Expanded experimental capabilities
Integrated workflow solutions centered on the TSQ Quantis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific Chromeleon Chromatography Data System (CDS) controls all experimental attributes in a regulated environment to further drive productivity.
Robust and reliable quantitation
Innovative designs in the ion source, neutral blocker, and mass analyzers maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance check and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.
Webinars
Highly sensitive and robust LC-MS/MS solutions for quantitation of nitrosamine impurities in metformin drug products
Learn more about a fit-for-purpose LC-SRM-MS method for the detection and quantitation of 10 nitrosamines in metformin drug products
Meet the TSQ Plus triple quadrupole mass spectrometers
Learn about the new hardware features driving next-level performance for targeted quantitation
The 40-year history of triple quadrupole development
The history of innovative triple quadrupole designs at Thermo Fisher Scientific
Tomorrow’s quantitation today – dynamic duo
The integrated process of connecting knowledge between method development and routine testing
Highly sensitive and robust LC-MS/MS solutions for quantitation of nitrosamine impurities in metformin drug products
Learn more about a fit-for-purpose LC-SRM-MS method for the detection and quantitation of 10 nitrosamines in metformin drug products
Meet the TSQ Plus triple quadrupole mass spectrometers
Learn about the new hardware features driving next-level performance for targeted quantitation
The 40-year history of triple quadrupole development
The history of innovative triple quadrupole designs at Thermo Fisher Scientific
Tomorrow’s quantitation today – dynamic duo
The integrated process of connecting knowledge between method development and routine testing
White Paper: Sensitivity and acquisition speed with triple quadrupole technology
Today’s analytical methods performing routine quantitation continue to evolve to meet new environmental and health risks. Experimental methods are modified to include more compounds measured at lower detection levels with faster gradients to address throughput. Therefore, specific LC-MS/MS performance characteristics are critical to evaluate productivity.
White Paper: Triple quadrupole mass spectrometer portfolio
Learn about the hardware and software innovations implemented in the TSQ triple quadrupole mass spectrometer platform to address the current and future challenges in targeted quantitation. The platform enhancements enable ultimate confidence in data quality with robust, reproducible, and reliable quantitative methodologies.
Expedite confident SRM transition creation: Integration of the Thermo Scientific mzCloud mass spectral database with the Thermo Scientific TSQ Plus mass spectrometer
Analytical labs adapt targeted quantitation methods to comply with regulations, adding new compounds to existing methods. Thermo Scientific mzCloud database integration with Thermo Scientific TSQ Plus mass spectrometers streamlines the process by importing SRM transitions, saving time and resources.
Resources
As we identify chemicals that pose environmental and health risks, it is critical to find effective and responsive solutions for routine quantitation to address current and emerging regulations. Your quantitative solutions must address a wide range of analytical requirements to screen and quantitate low-level chemical contaminants. These compounds and methods are diverse, requiring integrated solutions to respond quickly and confidently while meeting regulations.
Extraction and analysis of poly- and perfluoroalkyl substances (PFAS) from soil
Quantitation of cyanotoxins in drinking water according to EPA 544 guidelines
Reduced injection volume applied to the quantitation of cylindospermopsin and anatoxin-a in drinking water according to EPA Method 545
Quantitation of per- and polyfluoroalkyl substances (PFAS) in aqueous samples by LC-MS/MS following EPA Draft Method 1633
Additional resources
J. A. Bowden journal articles
PFAS toolkit
Perfluoroalkyl substances, or PFAS, are contaminants of increasing concern. We have the products and applications experience to help you achieve optimal analysis for PFAS compounds.
It is crucial to ensure safety and compliance for the world’s food supply, which is processed in different environments and under different regulations. Differences in pesticide development and implementation, as well as transportation and handling, make it complicated but important to develop workflow solutions to address current testing requirements as well as emerging threats and regulations. The TSQ Altis Plus mass spectrometer provides next-level performance to address these challenges.
Recent advancements in LC-MS/MS technology for enabling improvements in the multi-residue analysis of veterinary drugs in food
Meeting the challenges in pesticide residues analysis with the TSQ Quantis triple quadrupole mass spectrometer
Robustness, reproducibility, reliability with best-in-class sensitivity: increased confidence in targeted quantitation of pesticides in food matrices
Trace level quantitation of pesticide residues in leafy vegetables using LC-MS/MS
A multi-residue method for quantitation of pesticides in chicken, lamb, and fish using LC-MS/MS
Quantification of pesticide residues in rice, grape, tomato, and chili powder using LC-MS/MS
Additional resources
Explore solutions for food analytical testing
Thermo Fisher Scientific products and services can help your lab run seamlessly, while enabling you to expand your menu of food analyses with innovative instruments and connected data to transform your output
Food safety standards change and evolve
Ensuring the safety of the world’s food supply is critical, but there are concerns about the safety of global food supply chains because food can:
- Be grown and processed in widely differing environments under a variety of regulatory frameworks
- Travel thousands of miles and handled by many different operators and people
- Experience various storage conditions with temperature fluctuations that may affect shelf life
Providing innovative solutions to help meet the demanding needs of clinical, forensic, and toxicology research, Thermo Fisher Scientific workflow solutions combine effective front-end solutions to the TSQ Quantis and Quantis Plus mass spectrometers to deliver confident data.
All-in-one LC-MS/MS toxicology solution for drugs of abuse quantitation using the TSQ Quantis Plus mass spectrometer
Testing robustness: Immunosuppressant drugs in blood with a TSQ Quantis mass spectrometer for clinical research
Quantification of antiepileptics in human plasma or serum by liquid chromatography-tandem mass spectrometry for clinical research
Additional resources
Navigate with ease
Learn more about the Tox Explorer Collection, the all-in-one LC-MS/MS solution that provides confident answers to scientists in forensic toxicology, clinical research toxicology, employee drug testing, and sports anti-doping.
The bio/pharmaceutical drug development pipeline presents different challenges to researchers at every stage, from discovery through bioanalytical quantitation. Thermo Scientific TSQ Plus mass spectrometers leverage innovative hardware and software advancements to deliver productive solutions to enable our partners to deliver next-generation drugs to market faster with greater confidence.
Determination of six nitrosamine impurities in angiotensin II receptor blocker drugs by LC-MS/MS
Highly sensitive and robust LC-MS/MS solution for quantification of nitrosamine impurities in metformin drug products
Sensitive and robust determination of genotoxic AZBT impurity in six sartan drug products
Interested in the analysis of nitrosamines in pharmaceutics?
View this web page and download the latest applications notes, register for the latest webinars, and learn more about the analysis of nitrosamines and their precursor.
Nitrosamine Impurity Analysis
Nitrosamine impurity analysis requires robust and sensitive analytical methods to ensure confidence in the obtained results. The wide Thermo Scientific portfolio is proven to be excellent for nitrosamine analysis, ensuring your exploratory and routine methods are performed as accurately and reliably as possible while maintaining requirements from regulatory bodies worldwide. Our major products for the analysis of nitrosamines include:
- Liquid, gas, and ion chromatography for robust separation
- High-resolution, accurate-mass (HRAM) mass spectrometry for ultimate confidence avoiding false-positive results
- Tandem mass spectrometry, the best tool in routine analysis
- Single, compliance-ready software solution for all our technology solutions.
Related products
Connect your laboratory to drive more insights from your data
Thermo Fisher Connect Platform is part of our full suite of digital capabilities for secure, cloud-based data storage, scientific analysis apps, and peer collaboration tools. In addition, our asset management tools allow you to remotely schedule time on your lab’s instruments and monitor your run via your mobile device.
Using Thermo Fisher Connect, it’s easy to connect, save, and synchronize your files to your secure, personal account, which includes 1 TB of free storage. Peer and document collaboration tools enable secure group collaboration.
Style Sheet for Global Design System
Style Sheet for Komodo Tabs