Vivofectamine Delivery Solutions:
Advanced lipid nanoparticle technology

Lipid nanoparticle (LNP) technology has established itself  as a safe and effective delivery method for several successful nucleic acid therapeutics. With its versatility in delivering nucleic acids to multiple targets with therapeutic effect, LNP technology is becoming a cornerstone in the delivery of these novel medicines. Now, this technology is set to undergo further advancements, opening doors to new therapeutics by targeting the specific delivery of nucleic acids to many different targets for treating a wide array of diseases. Thermo Fisher Scientific is at the forefront of this exploration and development of lipid nanoparticle technology, helping pave the way for groundbreaking new medicines.

Discover a world of possibilities with Invitrogen Vivofectamine Delivery Solutions for utilizing lipid nanoparticle (LNP) technology. Rationally designed for in vivo delivery of nucleic acid vaccines and therapeutics, Vivofectamine products and services offer you a distinct edge in basic research and therapeutic development. These LNPs offer versatility, safety, and acceleration of your project timelines.

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Leveraging over 30 years of experience in lipid-based delivery, we’ve curated the Vivofectamine Delivery Solutions LNP portfolio. Drawing upon a vast library of more than 5,000 ionizable lipids, that were designed with complex multistep organic synthesis to maximize chemical diversity, the LNPs were selected for various applications. They were purposefully chosen through repeated cycles of lipid design, synthesis, formulation optimization, and both in vitro and in vivo screening for key characteristics like safety, delivery efficiency, and specificity.

For basic researchers, we offer off-the-shelf, easy-to-use LNP reagents in ethanol. One of these formulations is optimized for intramuscular mRNA vaccine delivery and the other is optimized for intravenous delivery to the liver.

Both reagents have demonstrated in vivo performance competitive with clinical benchmarks in rodent studies. These products are specifically designed with optimized lipid selection and composition tailored for each application. This can help to speed up your research by reducing the time required to find an appropriate LNP reagent to deliver your payload.

For drug developers, we have selected safe and effective ionizable lipids and designed formulations for intramuscular mRNA vaccine and intravenous liver delivery. These lipids offer an exceptional safety profile with delivery efficiency competitive with clinical benchmarks in rodents and non-human primates (NHP). We also offer solutions to explore in vivo delivery applications for systems such as CNS, eye, and tumors using a local route of delivery for potential nucleic acid therapeutics.

Flexible formats are available to meet your needs. Our drug development portfolio offers individual ionizable lipids to craft your own formulation, custom LNP compositions optimized for specific applications, and LNP formulation services to help accelerate your path to preclinical evaluations.

We offer you the flexibility to obtain a license for your chosen lipids for therapeutic use at your convenience. We prioritize tailoring our licenses to fit your unique business needs, providing scalable solutions that evolve with your growth.

Our solutions are well-characterized in animal models at a broad range of doses. The lipids in our drug development portfolio have been further tested in large animals (rats and non-human primates (NHP)), supporting their promise for further clinical development. Our data highlight that lipids in our drug development portfolio are tolerated at high or repeated doses.

Trusted in vivo delivery solutions can help accelerate your program. The meticulous selection and comprehensive testing that underpins the development of these LNP technologies helps reduce the time and resources often needed to identify the right LNP delivery solutions for your specific payload and application.

Leverage our extensive Invitrogen Lipofectamine transfection reagents and Vivofectamine Delivery Solutions to help accelerate your progress. Use Invitrogen Lipofectamine MessengerMAX reagent for in vitro mRNA target screening and/or quality control, then utilize Vivofectamine Delivery Solutions for efficient in vivo nucleic acid delivery. Whether you’re conducting basic research or developing breakthrough medicines, we’re here to support your journey.

The Vivofectamine Lipid Nanoparticle Delivery Solutions for drug developer portfolio is offered exclusively through our Vivofectamine Services team. For more information or to answer any questions you may have, contact our specialists today.

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