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This service can provide information that can supplement diagnoses of allograft injury via histopathology and other parameters.
In the post-transplant setting, data derived from the molecular profile of a biopsy can signal ongoing and often subclinical immune-mediated injury, as well as identify acute T cell-mediated rejection, even in samples without histological evidence of inflammation.1 This approach helps to overcome the limitations of conventional biopsy diagnosis, which often relies on histopathology scores that are empirically derived, subjective, and opinion-based.
MMDx Heart, MMDx Lung and MMDx Kidney complement conventional biopsy processing to help improve the assessment of rejection and injury in transplanted organs. These Laboratory Developed Tests use a GeneChip Custom Microarray to measure mRNA transcript levels in biopsies along with extensive big data derived from individuals and populations. The MMDx Heart and MMDx Kidney systems combine these technologies to deliver objective and reproducible transplant biopsy assessments on a molecular level.
mRNA is produced inside transplanted tissue when DNA genes are expressed or active
Depending on the risk or severity of organ rejection and injury, particular genes will be activated and produce unique patterns of mRNA
Thousands of different mRNA are accurately analyzed. The biopsy report provides a summary of key findings (eg, inflammation, acute kidney injury and atrophy-fibrosis scores and different rejection classifier scores) as well as the overall molecular interpretation
Obtaining results starts with requesting a free Specimen Collection Kit.
The illustration below shows how the sample is analyzed and the biopsy report is generated and made available to clinicians.
MMDx Heart, MMDx Lung and MMDx Kidney are tests that were developed and validated by Kashi Clinical Laboratories, Inc. The laboratory developed tests are used for clinical purposes by the CLIA-certified laboratory performing the test. These tests have not been cleared or approved by the US FDA or CE marked in the EU as an in vitro diagnostic test.
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