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Overview


The blood clotting system plays a vital role in controlling a bleed. This function is accomplished by the coordinated work of platelets and a set of circulating inactive clotting factors. Some individuals have genetic variations in one or more of their clotting factors that may predispose them to developing a clot, usually in a vein.

The most common inherited thrombophilia are:

  • Factor V Leiden (V is the Roman numeral for number 5), which affects 3-7% of the population
  • Prothrombin gene mutation G20210A, which affects 3-7% of the population
  • Deficiency of protein C, protein S, and antithrombin, each affecting less than 1% of the population

 

Product portfolio

Rely on a comprehensive portfolio of Applied Biosystems™ TaqPath Menu™ Thrombotic Mutations Kits

Factor II ProthrombinFactor XIII V34LMTHFR C677T
Factor V LeidenPAI-1 GenotypingMTHFR A1298C

Want to use our solutions?  Contact us for details on our limited time offer.

PCR Kit for Factor II Prothrombin

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of G20210A polymorphism in F2 gene for Factor II Prothrombin (rs1799963)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

PCR Kit for Factor V Leiden

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of G1691A Polymorphism in F5 gene for Factor V Leiden (rs6025)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

 Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

PCR Kit for XIII V34L

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of G103T Polymorphism in F13A1 gene for Factor XIII (V34L) (rs5985)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

PCR Kit for MTHFR A1298C

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of A1298C polymorphism in the gene for methylenetetrahydrofolate reductase (MTHFR) (rs1801131)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

PCR Kit for PAI-1 Genotyping

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of Polymorphism in SERPINE1 gene for Plasminogen activator inhibitor 1 (PAI-1) (rs1799762)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

PCR Kit for MTHFR C677T

Intended use and purpose:

  • Diagnostics and aid to diagnosis. Detection of C677T polymorphism in the gene for methylenetetrahydrofolate reductase (MTHFR) (rs1801133)​

Easy-to-use concept

  • Single tube ready-to-use Master Mix contains all components for PCR amplification
  • No additional pipetting of PCR reagents is necessary

Contamination reduction

  • Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination

Simple laboratory workflow

  • Easily combinable with other PCR kits from the TaqPath Menu PCR Kits in one workflow​
  • Compatible with a wide range of real-time PCR devices

CE-marked kit

Ordering information


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 Genetic Diagnostic of Thrombotic Mutations Brochure
 Checklist: TaqPath Menu Thrombotic Mutation Kits

For In Vitro Diagnostic Use.

Intended use and regulatory statements of products vary. For specific intended use and regulatory statements, please refer to the Instructions for Use (IFU).

Product availability by country varies. For product availability in your country, check the associated product webpages. TaqPath™ Menu | GeneProof™ assays are manufactured by GeneProof™ and distributed by Thermo Fisher Scientific.

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