Application Note: Demonstrating chemometric model transferability and monitoring upstream bioprocesses

Process Raman spectroscopy is a popular tool for real-time monitoring and control in bioprocessing. This application note discusses cultured cells for biologics manufacturing and the importance of efficient cell culture processes. Integrating the MarqMetrix All-In-One Process Raman Analyzer with bioreactors allowed the in-line measurement of critical process parameters.

In this application note, we will present the results of applying continuous in-line Raman spectroscopy to fed-batch and perfusion cell culture processes, demonstrating the accuracy and reliability of the analyzer in predicting parameters across different cell lines and media types.

Learn about several key topics in this application note:

• Developing more efficient cell culture processes.
• Predicting parameters across different cell lines and media types.
• Predicting parameters of interest accurately with chemometric models built using data from multiple instruments and bioreactors.