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Product Details
PA5-96680
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Furin (NP_0025601)
Conjugate
Form
Liquid
Concentration
2.34 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808482
Product Specific Information
Positive Samples: Mouse liver, Mouse kidney; Cellular Location: Cell membrane, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network membrane
Immunogen sequence: YSASWGPEDD GKTVDGPA
Target Information
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dibasic processing enzyme; Dibasic-processing enzyme; FES upstream region; Furin; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; PACE; Paired basic amino acid residue-cleaving enzyme; proprotein convertase subtilisin/kexin type 3
Gene Aliases: FUR; FURIN; PACE; PCSK3; SPC1
UniProt ID: (Human) P09958
Entrez Gene ID: (Human) 5045
signal peptide processing
transforming growth factor beta receptor signaling pathway
aging
cell proliferation
negative regulation of endopeptidase activity
protein processing
peptide hormone processing
viral life cycle
viral protein processing
extracellular matrix disassembly
extracellular matrix organization
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
collagen catabolic process
nerve growth factor processing
negative regulation of low-density lipoprotein particle receptor catabolic process
nerve growth factor production
negative regulation of nerve growth factor production
negative regulation of transforming growth factor beta1 production
secretion by cell
regulation of protein catabolic process
peptide biosynthetic process
cellular protein metabolic process
regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of membrane protein ectodomain proteolysis
regulation of endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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