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Human ADAMTS-13 quantitates human ADAMTS-13 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ADAMTS-13.
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : ADAM-TS13, ADAMTS-13, ADAMTS13, C9orf8, UNQ6102/PRO20085, vWF-CP, VWFCP
Gene ID : (Human) 11093
Gene symbol : ADAMTS13
Protein Aliases : A disintegrin and metalloproteinase with thrombospondin motifs 13, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13, ADAM metallopeptidase with thrombospondin type 1 motif, ADAM-TS 13, von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP
UniProt ID (Human) Q76LX8
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