Technical guide & protocol Tech Support

Product Specifications

Analytical sensitivity

0.13 ng/mL

Assay range

0.137-100 ng/mL

Sample type/volume

Plasma
50 µL
Serum
50 µL
Supernatant
50 µL

Hands-on time

1 hr 20 min

Time-to-result

4 hr 45 min

Homogenous (no wash)

No

Interassay CV

<12%

Intraassay CV

<10%

Instrument

Colorimetric Microplate Reader

Product size

96 Tests

Contents

Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers

Shipping conditions

Wet ice

Storage

2-8°C

Protein name

CYR61

Species (tested)

Human

Assay kit format

Sandwich ELISA Kit

Detector antibody conjugate

Biotin

Label or dye

HRP

About This Kit

Human Cyr61/CCN1 quantitates human Cyr61/CCN1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cyr61/CCN1.

Target information

CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Gene aliases : CCN1, CYR61, GIG1, IGFBP10

Gene ID : (Human) 3491

Gene symbol : CYR61

Protein Aliases : CCN family member 1, Cellular communication network factor 1, Cysteine-rich angiogenic inducer 61, cysteine-rich heparin-binding protein 61, cysteine-rich, angiogenic inducer, 61, anigogenic inducer, IBP-10, IGF-binding protein 10, IGFBP-10, Insulin-like growth factor-binding protein 10, Protein CYR61, Protein GIG1

UniProt ID (Human) O00622

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