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Product Specifications
Analytical sensitivity
0.82 ng/mL
Assay range
0.82-200 ng/mL
Sample type/volume
Supernatant
50 µL
Plasma
50 µL
Serum
50 µL
Hands-on time
1 hr 20 min
Time-to-result
4 hr 45 min
Homogenous (no wash)
No
Interassay CV
<12%
Intraassay CV
<10%
Instrument
Colorimetric Microplate Reader
Product size
96 Tests
Contents
Pre-coated 96 well plate
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
2-8°C
Protein name
S100A12
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
Human EN-RAGE/S100A12 quantitates human EN-RAGE/S100A12 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human EN-RAGE/S100A12.
Target information
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene aliases : CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100A12
Gene ID : (Human) 6283
Gene symbol : S100A12
Protein Aliases : CAAF1, CAGC, calcitermin, Calcium-binding protein in amniotic fluid 1, calgranulin C, Calgranulin-C, CGRP, EN-RAGE, Extracellular newly identified RAGE-binding protein, Migration inhibitory factor-related protein 6, MRP-6, Neutrophil S100 protein, Protein S100-A12, S100 calcium-binding protein A12, S100 calcium-binding protein A12 (calgranulin C)
UniProt ID (Human) P80511
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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