Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Human IL-23 R quantitates human IL-23 R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-23 R.
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : IL23R
Gene ID : (Human) 149233
Gene symbol : IL23R
Protein Aliases : IL-23 receptor, Interleukin-23 receptor
UniProt ID (Human) Q5VWK5
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