Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
900-K398K consists of: 900-K398 (capture antibody, detection antibody, and protein standard), and AVIDIN-60UL (avidin HRP-conjugate).
Human IL-33 ABTS ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant human IL-33 in a sandwich ELISA format. Human IL-33 ABTS ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The ABTS ELISA Buffer Kit (Product # 900-K00), sold separately, is recommended to be used in conjunction with this ABTS ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : C9orf26, DER4, DVS27, FIT-1, IL1F11, IL1RL1, IL33, IL33R, NF-HEV, NFEHEV, NFHEV, ST2, ST2L, ST2V, T1
Gene ID : (Human) 9173, (Human) 90865
Gene symbol : IL1RL1, IL33
Protein Aliases : DVS27-related protein, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, IL-1F11, IL-33, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, Interleukin-1 family member 11, Interleukin-1 receptor-like 1, Interleukin-33, NF-HEV, nuclear factor for high endothelial venules, Nuclear factor from high endothelial venules, Protein ST2
UniProt ID (Human) Q01638, (Human) O95760
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