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Human IL-34 quantitates human IL-34 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IL-34.
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : C16orf77, IL-34, IL34
Gene ID : (Human) 146433
Gene symbol : IL34
Protein Aliases : IL-34, Interleukin-34
UniProt ID (Human) Q6ZMJ4
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