Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Human JAM-A/CD321/F11R quantitates human JAM-A/CD321/F11R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human JAM-A/CD321/F11R.
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : CD321, F11R, JAM, JAM1, JAMA, JCAM, KAT, PAM-1, UNQ264/PRO301
Gene ID : (Human) 50848
Gene symbol : F11R
Protein Aliases : CD321, JAM-1, JAM-A, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM-1, Platelet adhesion molecule 1, Platelet F11 receptor
UniProt ID (Human) Q9Y624
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