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Human PILR-alpha quantitates human PILR-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human PILR-alpha.
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : FDF03, PILRA
Gene ID : (Human) 29992
Gene symbol : PILRA
Protein Aliases : Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, paired immunoglobin-like type 2 receptor alpha, Paired immunoglobulin-like type 2 receptor alpha
UniProt ID (Human) Q9UKJ1
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