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Human ULBP-2/ALCAN-alpha/N2DL2 quantitates human ULBP-2/ALCAN-alpha/N2DL2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ULBP-2/ALCAN-alpha/N2DL2.
ULBP2 encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, ULBP2, UNQ463/PRO791
Gene ID : (Human) 80328
Gene symbol : ULBP2
Protein Aliases : ALCAN-alpha, N2DL-2, NKG2D ligand 2, Retinoic acid early transcript 1H, UL16-binding protein 2
UniProt ID (Human) Q9BZM5
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