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Rat Notch-1 quantitates rat Notch-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat Notch-1.
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : NOTCH, Notch1, TAN1
Gene ID : (Rat) 25496
Gene symbol : Notch1
Protein Aliases : Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila), Neurogenic locus notch homolog protein 1, Notch 1, Notch gene homolog 1
UniProt ID (Rat) Q07008
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