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This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
AI194696; CFHL; Cfhl1; CFHL1P; CFHR1; CFHR1P; CFHRB; complement component factor h-like 1; complement factor H related 1; complement factor H-related 1; complement factor H-related 1 pseudogene; complement factor H-related protein; complement factor H-related protein 1; FHR1; FHR-1; H factor (complement)-like 1; H factor (complement)-like 2; h factor-like protein 1; H36; H36-1; H36-2; H-factor-like 1; HFL1; HFL2
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