Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
AU015004; Crim1; CRIM-1; cysteine rich transmembrane BMP regulator 1; cysteine rich transmembrane BMP regulator 1 (chordin like); cysteine rich transmembrane BMP regulator 1 (chordin-like); cysteine-rich motor neuron 1; cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52; Processed cysteine-rich motor neuron 1 protein; S52; UNQ1886/PRO4330
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support