Thinking about investing in a new HPLC system?

The HPLC System Total Cost of Ownership Calculator helps you estimate your total cost for purchasing and running a Thermo Scientific HPLC system over a designated time period. Compare against other instruments to find the best product for you. 

Input your typical system use conditions and typical consumable costs associated with your current set-up to estimate many samples you can run in a year along with the expected cost per sample. See how applying tandem and dual LC workflows can increase your productivity and help reduce cost per sample for a quicker return on your investment.

Use at your own risk. Prepopulated data are estimates only. Thermo Fisher Scientific takes no responsibility for the accuracy of data, calculations or results.

Step 1: Choose a preset process OR start with minimum conditionals. After, enter your own adjustments.

Minimum conditionals

or

Preset process

    

Additional experiment conditions

Format: 1000; not 1,000.00
Not required for Isocratic conditions

Step 2: Review the results

Step 3: Review the charts


Number of Systems Required to Achieve
Target Number of Samples Per Year

Single
Tandem
Dual

Number of Samples Per Day
 

Step 4: Compare

Most accurate results require content in these fields

Single Channel LCTandem LC or LC-MSDual LC

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System Cost ($)
Yearly Maintenance Costs ($)
Yearly Labor and Overhead Costs ($)
Additional Cost Per Sample ($)
System Type
Cost Per Sample ($)
Based on the maximum number of samples
Number of Samples Per Day Per System
Number of Samples Per Year Per System
Yearly System, Maintenance, Overhead Costs ($)
Yearly Column and Consumable Costs ($)
Yearly Solvent Costs ($)
System ASystem B
System Cost ($)
Yearly Maintenance Costs ($)
Yearly Labor and Overhead Costs ($)
Additional Cost Per Sample ($)
System Type
Cost Per Sample ($)
Based on the maximum number of samples
Number of Samples Per Day Per System
Number of Samples Per Year Per System
Yearly System, Maintenance, Overhead Costs ($)
Yearly Column and Consumable Costs ($)
Yearly Solvent Costs ($)

Step 5: Choose product

Vanquish Core HPLC SystemsVanquish Flex UHPLC SystemsVanquish Horizon UHPLC SystemsVanquish Neo UHPLC System
General application
Dependable routine HPLC analysisFlexible HPLC and UHPLC method developmentTop performance and resolution for demanding UHPLC separationsMaximum low-flow performance for high-sensitivity LC-MS workflows
Pump options
Binary, Quaternary, Dual and IsocraticBinary, Quaternary and DualBinaryBinary
System pressure
Up to 700 barUp to 1000 barUp to 1500 barUp to 1500 bar
Flow range
0.001 – 10 mL/min0.001 – 8 mL/min0.001 – 5 mL/min 1 nL/min – 100 µL/min
Biocompatible
NoYesYesYes
Common detector setup
Up to 2 detectors and/or 1 mass spectrometerUp to 2 detectors and/or 1 mass spectrometerUp to 2 detectors and/or 1 mass spectrometer1 VWD and/or 1 mass spectrometer
Vanquish Duo UHPLC SystemsTranscend VLX-2 UHPLC SystemsVanquish Tandem LC Systems
Benefit
Doubled productivity with 2 independent UHPLC channels built into one stackIntegrated multi-channel LC for ultra-high-throughput LC-MSMaximized detector utilization by using offline column reconditioning
Supported systems
Vanquish Flex
Vanquish Horizon
Vanquish Flex
Vanquish Horizon
Vanquish Core
Vanquish Flex
Vanquish Horizon
Common detector setup
1-2 detectors per channel
(2-4 detectors per system)
1 mass spectrometerUp to 2 detectors and/or 1 mass spectrometer
Software control
Thermo Scientific Chromeleon CDS
Thermo Scientific Standard System
Integration for Waters™ Empower™ 3 CDS software
Thermo Scientific Aria MX softwareThermo Scientific Chromeleon CDS
Thermo Scientific Standard System
Integration for Thermo Scientific XCalibur software
Vanquish Flex Duo Ternary UHPLC System with 2 Detectors
Pump type:DPG (Vanquish Dual Pump F)
Maximum pressure:1000 bar, 15,000 psi
Autosampler:Dual (Vanquish Dual Split Sampler FT)
Column switching:N/A
Detectors required:2 x Vanquish Detectors and/or Mass Spectrometer
Vanquish Flex Duo Binary UHPLC System with 2 Detectors
Pump type:2 x HPG (Vanquish Binary Pump F)
Maximum pressure:1000 bar, 15,000 psi
Autosampler:Dual (Vanquish Dual Split Sampler FT)
Column switching:N/A
Detectors required:2 x Vanquish Detectors and/or Mass Spectrometer
Vanquish Horizon Duo Binary UHPLC System with 2 Detectors
Pump type:2 x HPG (Vanquish Binary Pump H)
Maximum pressure:1500 bar, 22,000 psi
Autosampler:Dual (Vanquish Dual Split Sampler HT)
Column switching:N/A
Detectors required:2 x Vanquish Detectors and/or Mass Spectrometer
CMD SchemaApp code