HPLC System Cost Comparison Calculator

Thinking about investing in a new HPLC system?

The HPLC System Total Cost of Ownership Calculator helps you estimate your total cost for purchasing and running a Thermo Scientific HPLC system over a designated time period. Compare against other instruments to find the best product for you.

Input your typical system use conditions and typical consumable costs associated with your current set-up to estimate many samples you can run in a year along with the expected cost per sample. See how applying tandem and dual LC workflows can increase your productivity and help reduce cost per sample for a quicker return on your investment.

Use at your own risk. Prepopulated data are estimates only. Thermo Fisher Scientific takes no responsibility for the accuracy of data, calculations or results.

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Step 1: Choose a preset process OR start with minimum conditionals. After, enter your own adjustments.

Minimum conditionals

Gradient Time (min)

Wash and Equilibration (min)

Select Currency

or

Preset process

Additional experiment conditions

Gradient Delay Volume (µL)

Flow Rate (µL/min)

Cost Per Column ($)

Solvent Cost Per Liter ($)

Solvent Waste Cost Per Liter ($)

Additional Cost Per Sample ($)

Yearly Labor and Overhead Costs ($)

Years of System Use

Days of System Use Per Year

Injections Per ColumnFormat: 1000; not 1,000.00

Use Equilibration Time Calculator?Not required for Isocratic conditions

Step 2: Review the results

Step 3: Review the charts

Number of Systems Required to Achieve
Target Number of Samples Per Year

Single
Tandem
Dual

Number of Samples Per Day

Step 4: Compare

Most accurate results require content in these fields

	Single Channel LC	Tandem LC or LC-MS	Dual LC
	Click to enlarge	Click to enlarge	Click to enlarge
System Cost ($)
Yearly Maintenance Costs ($)
Yearly Labor and Overhead Costs ($)
Additional Cost Per Sample ($)
System Type
Cost Per Sample ($) Based on the maximum number of samples

Number of Samples Per Day Per System
Number of Samples Per Year Per System
Yearly System, Maintenance, Overhead Costs ($)
Yearly Column and Consumable Costs ($)
Yearly Solvent Costs ($)

	System A	System B
System Cost ($)
Yearly Maintenance Costs ($)
Yearly Labor and Overhead Costs ($)
Additional Cost Per Sample ($)
System Type
Cost Per Sample ($) Based on the maximum number of samples

Number of Samples Per Day Per System
Number of Samples Per Year Per System
Yearly System, Maintenance, Overhead Costs ($)
Yearly Column and Consumable Costs ($)
Yearly Solvent Costs ($)

Step 5: Choose product

Vanquish Core HPLC Systems	Vanquish Flex UHPLC Systems	Vanquish Horizon UHPLC Systems	Vanquish Neo UHPLC System
General application
Dependable routine HPLC analysis	Flexible HPLC and UHPLC method development	Top performance and resolution for demanding UHPLC separations	Maximum low-flow performance for high-sensitivity LC-MS workflows
Pump options
Binary, Quaternary, Dual and Isocratic	Binary, Quaternary and Dual	Binary	Binary
System pressure
Up to 700 bar	Up to 1000 bar	Up to 1500 bar	Up to 1500 bar
Flow range
0.001 – 10 mL/min	0.001 – 8 mL/min	0.001 – 5 mL/min	1 nL/min – 100 µL/min
Biocompatible
No	Yes	Yes	Yes
Common detector setup
Up to 2 detectors and/or 1 mass spectrometer	Up to 2 detectors and/or 1 mass spectrometer	Up to 2 detectors and/or 1 mass spectrometer	1 VWD and/or 1 mass spectrometer

Vanquish Duo UHPLC Systems	Transcend VLX-2 UHPLC Systems	Vanquish Tandem LC Systems
Benefit
Doubled productivity with 2 independent UHPLC channels built into one stack	Integrated multi-channel LC for ultra-high-throughput LC-MS	Maximized detector utilization by using offline column reconditioning
Supported systems
Vanquish Flex Vanquish Horizon	Vanquish Flex Vanquish Horizon	Vanquish Core Vanquish Flex Vanquish Horizon
Common detector setup
1-2 detectors per channel (2-4 detectors per system)	1 mass spectrometer	Up to 2 detectors and/or 1 mass spectrometer
Software control
Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Waters™ Empower™ 3 CDS software	Thermo Scientific Aria MX software	Thermo Scientific Chromeleon CDS Thermo Scientific Standard System Integration for Thermo Scientific XCalibur software

Vanquish Flex Duo Ternary UHPLC System with 2 Detectors
Pump type:	DPG (Vanquish Dual Pump F)
Maximum pressure:	1000 bar, 15,000 psi
Autosampler:	Dual (Vanquish Dual Split Sampler FT)
Column switching:	N/A
Detectors required:	2 x Vanquish Detectors and/or Mass Spectrometer

Vanquish Flex Duo Binary UHPLC System with 2 Detectors
Pump type:	2 x HPG (Vanquish Binary Pump F)
Maximum pressure:	1000 bar, 15,000 psi
Autosampler:	Dual (Vanquish Dual Split Sampler FT)
Column switching:	N/A
Detectors required:	2 x Vanquish Detectors and/or Mass Spectrometer

Vanquish Horizon Duo Binary UHPLC System with 2 Detectors
Pump type:	2 x HPG (Vanquish Binary Pump H)
Maximum pressure:	1500 bar, 22,000 psi
Autosampler:	Dual (Vanquish Dual Split Sampler HT)
Column switching:	N/A
Detectors required:	2 x Vanquish Detectors and/or Mass Spectrometer

CMD SchemaApp code